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General

Strain: F344-Nrg1^{Tn(sb-T2/Bart3)2.183Mcwi}

Symbol:

F344-Nrg1^{Tn(sb-T2/Bart3)2.183Mcwi}

Strain:

F344-Nrg1^{Tn(sb-T2/Bart3)2.183}

Substrain:

Mcwi

Ontology ID:

RS:0001271

Alleles:

Nrg1^{Tn(sb-T2/Bart3)2.183Mcwi}

Also known as:

F344-Nrg1Tn(sb-T2/Bart3)2.183Mcwi; RRRC:00343

Type:

mutant

Source:

PhysGen, Transposagen, Rat Resource and Research Center

Origin:

this Sleeping Beauty mutants were derived by crossing F344-TgTn(T2/Bart3)2Ceb and F344-Tg(PGK2-sb11)Ceb. This mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the 1st intron of the Nrg1 gene.

Last Known Status:

Cryopreserved Sperm (as of 2017-01-26)

Position

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	16	62,969,573 - 64,065,063	RGD_MAPPER_PIPELINE	Rnor6.0
Rnor_5.0	16	62,632,432 - 63,718,738	RGD_MAPPER_PIPELINE	Rnor5.0
RGSC_v3.4	16	63,937,796 - 64,126,183	RGD_MAPPER_PIPELINE	RGSC3.4

Annotation (Toggle Annotation Detail/Summary View)

Phenotype Values via Phenominer

Related Phenotype Data for Term "F344-Nrg1Tn(sb-T2/Bart3)2.183Mcwi" (RS:0001271)

Rat Strains:

F344-Nrg1Tn(sb-T2/Bart3)2.183Mcwi

Clinical Measurements:

acetylcholine-induced blood vessel dilation expressed as percent of force at maximum constriction
blood eosinophil count
blood hemoglobin level
blood lymphocyte count
blood monocyte count
blood neutrophil count
body length, nose to rump
body length, nose to tail
body weight
concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50)
concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50)
heart left ventricle wet weight
heart right ventricle wet weight
heart wet weight
hematocrit
left kidney wet weight
logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)
logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50)
maximum contractile force per wet weight of aorta
mean corpuscular hemoglobin concentration
mean corpuscular hemoglobin level
mean corpuscular volume
plasma anion gap
plasma creatinine level
red blood cell count
serum alanine aminotransferase activity level
serum albumin level
serum alkaline phosphatase activity level
serum aspartate aminotransferase activity level
serum bicarbonate level
serum calcium level
serum chloride level
serum globulin level
serum glucose level
serum phosphate level
serum potassium level
serum sodium level
serum total cholesterol level
serum total protein level
serum urea nitrogen level
total serum bilirubin level
total white blood cell count

Experimental Conditions:

acetylcholine
controlled sodium content diet
drug dose time series
fasting
phenylephrine
potassium ion

Measurement Methods:

automated blood cell counting method
automated plasma creatinine analysis
digital scale post excision weight measurement
flame atomic emission spectrometry
in vivo ruler method
standard blood chemistry panel
whole body digital scale
wire myography using a Digi-Med tissue force analysis system with force transducer

Experimental Data Annotations

Rat Strain

F344-Nrg1Tn(sb-T2/Bart3)2.183Mcwi (IEA)

Phenotype Values via Phenominer

Options:

View chart

Download data table

View expanded data table

Clinical Measurement

body weight

red blood cell count

blood hemoglobin level

blood neutrophil count

blood lymphocyte count

blood monocyte count

blood eosinophil count

hematocrit

mean corpuscular volume

plasma anion gap

heart wet weight

heart left ventricle wet weight

heart right ventricle wet weight

body length, nose to tail

body length, nose to rump

left kidney wet weight

mean corpuscular hemoglobin level

mean corpuscular hemoglobin concentration

serum total cholesterol level

total white blood cell count

total serum bilirubin level

serum bicarbonate level

serum chloride level

serum potassium level

serum sodium level

serum calcium level

plasma creatinine level

serum phosphate level

serum glucose level

serum albumin level

serum alanine aminotransferase activity level

serum alkaline phosphatase activity level

serum aspartate aminotransferase activity level

serum urea nitrogen level

serum total protein level

concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50)

logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50)

concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50)

logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)

maximum contractile force per wet weight of aorta

acetylcholine-induced blood vessel dilation expressed as percent of force at maximum constriction

serum globulin level

References - curated

1.	Lu B, etal., Mamm Genome. 2007 May;18(5):338-46. Epub 2007 Jun 8.
2.	Personal Communication with Rat Resource & Research Center
3.	PhysGen strains
4.	RGD Automated Pipelines

Region

Additional Information

Nomenclature History

Date	Current Symbol	Previous Symbol	Description	Reference	Status
2014-03-24	F344-Nrg1^{Tn(sb-T2/Bart3)2.183Mcwi}	F344-Nrg1^{Tn(sb-T2/Bart3)2.183Mcwi}	Symbol updated	68687	APPROVED
2014-03-24	F344-Nrg1^{Tn(sb-T2/Bart3)2.183Mcwi}	F344-Nrg1^{Tn(sb-T2/Bart3)2.183Mcwi}	Name updated	68913	APPROVED
2014-03-24	F344-Nrg1^{Tn(sb-T2/Bart3)2.183Mcwi}	F344-Nrg1^{Tn(sb-T2/Bart3)2.183Mcwi}	Symbol updated	68687	APPROVED
2014-03-24	F344-Nrg1^{Tn(sb-T2/Bart3)2.183Mcwi}	F344-Nrg1^{Tn(sb-T2/Bart3)2.183Mcwi}	Name updated	68913	APPROVED
2012-04-17	F344-Nrg1^{Tn(sb-T2/Bart3)2.183Mcwi}	F344-Nrg1^{Tn(sb-T2/Bart3)2.183Mcwi}	Name updated	68913	APPROVED
2012-04-17	F344-Nrg1^{Tn(sb-T2/Bart3)2.183Mcwi}	F344-Nrg1^{Tn(sb-T2/Bart3)2.183Mcwi}	Name updated	68913	APPROVED
2010-06-08	F344-Nrg1^{Tn(sb-T2/Bart3)2.183Mcwi}	F344-Nrg1^{Tn(sb-T2/Bart3)2.183Mcwi}	Name updated	68913	APPROVED
2010-06-08	F344-Nrg1^{Tn(sb-T2/Bart3)2.183Mcwi}	F344-Nrg1^{Tn(sb-T2/Bart3)2.183}/Mcwi	Name updated	68913	APPROVED
2010-06-08	F344-Nrg1^{Tn(sb-T2/Bart3)2.183Mcwi}	F344-Nrg1^{Tn(sb-T2/Bart3)2.183}/Mcwi	Symbol updated	68687	APPROVED
2010-06-08	F344-Nrg1^{Tn(sb-T2/Bart3)2.183Mcwi}	F344-Nrg1^{Tn(sb-T2/Bart3)2.183}/Mcwi	Name updated	68913	APPROVED
2010-06-08	F344-Nrg1^{Tn(sb-T2/Bart3)2.183Mcwi}	F344-Nrg1^{Tn(sb-T2/Bart3)2.183}/Mcwi	Symbol updated	68687	APPROVED
2010-06-08	F344-Nrg1^{Tn(sb-T2/Bart3)2.183Mcwi}	F344-Nrg1^{Tn(sb-T2/Bart3)2.183Mcwi}	Name updated	68913	APPROVED

External Database Links

Database	Acc Id	Source(s)
Transposagen	Nrg1	Transposagen

More on this Strain
	Strain Nomenclature
	Strain Registration

RGD Object Information
RGD ID:	2290103
Created:	2008-02-26
Species:	Rattus norvegicus
Last Modified:	2017-01-26
Status:	ACTIVE

Functional Annotation unavailable	Annotation Distribution unavailable	Genomic Variants unavailble Genomic Variants unavailable
Functional Annotation	Annotation Distribution	Genomic Variants

Protein-Protein Interactions unavailable	Genome Viewer unavailable	Damaging Variants unavailble Damaging Variants unavailable
Protein-Protein Interactions	Genome Viewer	Damaging Variants

Annotation Comparison unavailable	OLGA unavailable
Annotation Comparison	OLGA	Excel (Download)

Create Name:

Description:

Strain: F344-Nrg1Tn(sb-T2/Bart3)2.183Mcwi

Related Phenotype Data for Term "F344-Nrg1Tn(sb-T2/Bart3)2.183Mcwi" (RS:0001271)

Strain: F344-Nrg1^{Tn(sb-T2/Bart3)2.183Mcwi}