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Strain Registration

Strain: F344-Nrg1Tn(sb-T2/Bart3)2.183Mcwi

Symbol: F344-Nrg1Tn(sb-T2/Bart3)2.183Mcwi
Strain: F344-Nrg1Tn(sb-T2/Bart3)2.183
Substrain: Mcwi
RGD ID: 2290103
Citation ID: RRID:RRRC_00343
Ontology ID: RS:0001271
Alleles: Nrg1Tn(sb-T2/Bart3)2.183Mcwi
Previously known as: F344-Nrg1Tn(sb-T2/Bart3)2.183Mcwi
Type: mutant
Source: PhysGen, Transposagen, Rat Resource and Research Center
Origin: this Sleeping Beauty mutants were derived by crossing F344-TgTn(T2/Bart3)2Ceb and F344-Tg(PGK2-sb11)Ceb. This mutation consists of an insertion of a Sleeping Beauty transposable element gene trap construct into the 1st intron of the Nrg1 gene.
Last Known Status: Cryopreserved Sperm (as of 2017-01-26)
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21659,250,658 - 60,303,024RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.01662,969,573 - 64,065,063RGD_MAPPER_PIPELINERnor6.0
Rnor_5.01662,632,432 - 63,718,738RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.41663,937,796 - 64,126,183RGD_MAPPER_PIPELINERGSC3.4





Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype

Phenotype Values via PhenoMiner     Click to see Annotation Detail View
Options:  View chart  |  Download data table  |  View expanded data table

Clinical Measurement
body weight
red blood cell count
blood hemoglobin level
blood neutrophil count
blood lymphocyte count
blood monocyte count
blood eosinophil count
hematocrit
mean corpuscular volume
plasma anion gap
heart wet weight
heart left ventricle wet weight
heart right ventricle wet weight
body length, nose to tail
body length, nose to rump
left kidney wet weight
mean corpuscular hemoglobin
mean corpuscular hemoglobin concentration
serum total cholesterol level
total white blood cell count
serum total bilirubin level
serum bicarbonate level
serum chloride level
serum potassium level
serum sodium level
serum calcium level
plasma creatinine level
serum phosphate level
serum glucose level
serum albumin level
serum alanine aminotransferase activity level
serum alkaline phosphatase activity level
serum aspartate aminotransferase activity level
serum urea nitrogen level
serum total protein level
concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50)
logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50)
concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50)
logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)
maximum contractile force per wet weight of aorta
acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel
serum globulin level

References

References - curated
# Reference Title Reference Citation
1. Generation of rat mutants using a coat color-tagged Sleeping Beauty transposon system. Lu B, etal., Mamm Genome. 2007 May;18(5):338-46. Epub 2007 Jun 8.
2. Data registered by the Rat Resource & Research Center Personal Communication with Rat Resource & Research Center
3. PhysGen Strains PhysGen strains
4. RGD Strain RSO annotation pipeline RGD Automated Pipelines
5. The interaction of disrupted type II neuregulin 1 and chronic adolescent stress on adult anxiety- and fear-related behaviors. Taylor SB, etal., Neuroscience. 2013 Sep 26;249:31-42. doi: 10.1016/j.neuroscience.2012.09.045. Epub 2012 Sep 25.
6. Disruption of the neuregulin 1 gene in the rat alters HPA axis activity and behavioral responses to environmental stimuli. Taylor SB, etal., Physiol Behav. 2011 Aug 3;104(2):205-14. doi: 10.1016/j.physbeh.2010.11.015. Epub 2010 Nov 16.

Region


Additional Information


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-03-24 F344-Nrg1Tn(sb-T2/Bart3)2.183Mcwi    F344-Nrg1Tn(sb-T2/Bart3)2.183Mcwi    Symbol updated 68687 APPROVED
2014-03-24 F344-Nrg1Tn(sb-T2/Bart3)2.183Mcwi    F344-Nrg1Tn(sb-T2/Bart3)2.183Mcwi    Name updated 68913 APPROVED
2014-03-24 F344-Nrg1Tn(sb-T2/Bart3)2.183Mcwi    F344-Nrg1Tn(sb-T2/Bart3)2.183Mcwi    Symbol updated 68687 APPROVED
2014-03-24 F344-Nrg1Tn(sb-T2/Bart3)2.183Mcwi    F344-Nrg1Tn(sb-T2/Bart3)2.183Mcwi    Name updated 68913 APPROVED
2012-04-17 F344-Nrg1Tn(sb-T2/Bart3)2.183Mcwi    F344-Nrg1Tn(sb-T2/Bart3)2.183Mcwi    Name updated 68913 APPROVED
2012-04-17 F344-Nrg1Tn(sb-T2/Bart3)2.183Mcwi    F344-Nrg1Tn(sb-T2/Bart3)2.183Mcwi    Name updated 68913 APPROVED
2010-06-08 F344-Nrg1Tn(sb-T2/Bart3)2.183Mcwi    F344-Nrg1Tn(sb-T2/Bart3)2.183Mcwi    Name updated 68913 APPROVED
2010-06-08 F344-Nrg1Tn(sb-T2/Bart3)2.183Mcwi    F344-Nrg1Tn(sb-T2/Bart3)2.183/Mcwi    Name updated 68913 APPROVED
2010-06-08 F344-Nrg1Tn(sb-T2/Bart3)2.183Mcwi    F344-Nrg1Tn(sb-T2/Bart3)2.183/Mcwi    Symbol updated 68687 APPROVED
2010-06-08 F344-Nrg1Tn(sb-T2/Bart3)2.183Mcwi    F344-Nrg1Tn(sb-T2/Bart3)2.183/Mcwi    Name updated 68913 APPROVED
2010-06-08 F344-Nrg1Tn(sb-T2/Bart3)2.183Mcwi    F344-Nrg1Tn(sb-T2/Bart3)2.183/Mcwi    Symbol updated 68687 APPROVED
2010-06-08 F344-Nrg1Tn(sb-T2/Bart3)2.183Mcwi    F344-Nrg1Tn(sb-T2/Bart3)2.183Mcwi    Name updated 68913 APPROVED

Database Acc Id Source(s)
RRRC RRRC:00343 RGD