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Strain Registration

Strain: SD-Brca2m1Uwm

Symbol: SD-Brca2m1Uwm
Strain: SD-Brca2m1
Substrain: Uwm
RGD ID: 1641865
Citation ID: RRID:RRRC_00286
Ontology ID: RS:0001384
Alleles: Brca2m1Uwm
Previously known as: SD-Brca2m1Uwm; SD-Brca2m1Uwm
Type: mutant
Source: University of Wisconsin-Madison, Madison, Wisconsin, Rat Resource and Research Center
Origin: 9 week-old male rats were injected with ENU (N-ethyl-N-nitrosourea) and then bred. Phenotypically variant pups were visually identified and screened. Nonsense transversion mutation at nucleotide T4254 that converted TAT (tyrosine) to TAA (stop codon).
Last Known Status: Cryopreserved Embryo; Cryopreserved Sperm (as of 2016-12-01)
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21259,492 - 103,789RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.012503,660 - 544,754RGD_MAPPER_PIPELINERnor6.0
Rnor_5.012490,733 - 535,090RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.4124,282,952 - 4,323,693RGD_MAPPER_PIPELINERGSC3.4





Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

References

References - curated
# Reference Title Reference Citation
1. Characterizing a rat Brca2 knockout model. Cotroneo MS, etal., Oncogene. 2006 Sep 11;.
2. Data registered by the Rat Resource & Research Center Personal Communication with Rat Resource & Research Center
3. RGD Strain RSO annotation pipeline RGD Automated Pipelines
4. Production of knockout rats using ENU mutagenesis and a yeast-based screening assay. Zan Y, etal., Nat Biotechnol 2003 Jun;21(6):645-51.

Region

Allelic Variants
Name Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Assembly
Brca2m1Uwm-var1 chr12 74070 74070 T A point_mutation mRatBN7.2
Brca2m1Uwm-var1 chr12 518257 518257 T A point_mutation Rnor_6.0

Additional Information


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-05-28 SD-Brca2m1Uwm    SD-Brca2m1Uwm    gene nomenclature is perpetuated to the strain symbol 2293819 APPROVED
2014-04-28 SD-Brca2m1Uwm    SD-Brca2m1Uwm    gene nomenclature is perpetuated to the strain symbol 2293819 APPROVED
2014-03-28 SD-Brca2m1Uwm    SD-Brca2m1Uwm    gene nomenclature is perpetuated to the strain symbol 2293819 APPROVED
2014-03-21 SD-Brca2m1Uwm    SD-Brca2m1Uwm    Name updated 68913 APPROVED
2014-03-21 SD-Brca2m1Uwm    SD-Brca2m1Uwm    Name updated 68913 APPROVED
2014-03-21 SD-Brca2m1Uwm    SD-Brca2m1Uwm    Symbol updated 68687 APPROVED
2014-03-21 SD-Brca2m1Uwm    SD-Brca2m1Uwm    Symbol updated 68687 APPROVED
2012-04-18 SD-Brca2m1Uwm    SD-Brca2m1Uwm    Name updated 68913 APPROVED
2012-04-18 SD-Brca2m1Uwm    SD-Brca2m1Uwm    Name updated 68913 APPROVED
2011-12-02 SD-Brca2m1Uwm    SD-Brca2m1Uwm    Name updated 68913 APPROVED
2011-12-02 SD-Brca2m1Uwm    SD-Brca2m1Uwm    Name updated 68913 APPROVED

Database Acc Id Source(s)
RRRC RRRC:00286 RGD