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Strain: LEW-Tg(Ren2)27/Jmul

Symbol: LEW-Tg(Ren2)27/Jmul
Strain: LEW-Tg(Ren2)27
Substrain: Jmul
RGD ID: 1600341
Citation ID: RRID:RGD_1600341
Ontology ID: RS:0001350
Also Known As: Lew.Tg(mRen2); mRen(2).Lewis;mRen(2).Lew
Type: transgenic
Available Source: Not Available
Origination: Wake Forest University School of Medicine, Winston-Salem, North Carolina
Description: This is a transgenic hypertensive rat strain, the mouse Ren2, renin gene is microinjected into fertilized eggs of LEW/Crl rats
Last Known Status: Unknown





References

References - curated
# Reference Title Reference Citation
1. Effect of angiotensin II blockade on a new congenic model of hypertension derived from transgenic Ren-2 rats. Jessup JA, etal., Am J Physiol Heart Circ Physiol. 2006 Nov;291(5):H2166-72. Epub 2006 Jun 9.
2. Sex differences in circulating and renal angiotensins of hypertensive mRen(2).Lewis but not normotensive Lewis rats. Pendergrass KD, etal., Am J Physiol Heart Circ Physiol. 2008 Jul;295(1):H10-20. Epub 2008 May 2.
3. Sex Differences in Circulating and Renal Angiotensins of Hypertensive mRen(2).Lewis but not Normotensive Lewis Rats. Pendergrass KD, etal., Am J Physiol Heart Circ Physiol. 2008 May 2;.
4. RGD Strain RSO annotation pipeline RGD Automated Pipelines

Region


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_drgs_chems Lisinopril and losartan significantly decrease the systolic blood pressure and reverse proteinuria. 1600133
strain_life_disease males exhibit higher systolic blood pressure as compared to females and also LEW rats 2293121
strain_phys_biochem Plasma angiotensin II levels were two-fold higher in males and 5-fold higher as compared to LEW rats 2293121
strain_phys_biochem Females display higher levels of circulating plasma angiotensin (1-7) 2293121

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-03-30 LEW-Tg(Ren2)27/Jmul    LEW-Tg(Ren2)27    Symbol updated 68687 APPROVED
2017-03-30 LEW-Tg(Ren2)27/Jmul    LEW-Tg(Ren2)27    Symbol updated 68687 APPROVED