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Strain: DA/BklArbNsi

Symbol: DA/BklArbNsi
Strain: DA
Substrain: BklArbNsi
RGD ID: 1600340
Citation ID: RRID:RRRC_00693
Ontology ID: RS:0001227
Previously known as: SPRD-Cu3
Type: inbred
Source: Feinstein Institute for Medical Research at North Shore-LIJ, Manhasset, NY, Rat Resource and Research Center
Origin: Originally purchased from Bantin and Kingman, Fremont, California, maintained at the National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH. This was then transferred to Feinstein Institute for Medical Research at North Shore-LIJ, which was formerly known as North Shore-LIJ Research Institute, NSI.
Inbred Generations: F51
Last Known Status: Cryopreserved Embryo; Cryopreserved Sperm (as of 2017-01-26)





References

References - curated
# Reference Title Reference Citation
1. The non-MHC quantitative trait locus Cia5 contains three major arthritis genes that differentially regulate disease severity, pannus formation, and joint damage in collagen- and pristane-induced arthritis. Brenner M, etal., J Immunol 2005 Jun 15;174(12):7894-903.
2. The cation channel Trpv2 is a new suppressor of arthritis severity, joint damage, and synovial fibroblast invasion. Laragione T, etal., Clin Immunol. 2015 Apr 11. pii: S1521-6616(15)00131-X. doi: 10.1016/j.clim.2015.04.001.
3. The Arthritis Severity Quantitative Trait Loci Cia4 and Cia6 Regulate Neutrophil Migration into Inflammatory Sites and Levels of TNF-{alpha} and Nitric Oxide. Laragione T, etal., J Immunol. 2007 Feb 15;178(4):2344-51.
4. Data registered by the Rat Resource & Research Center Personal Communication with Rat Resource & Research Center
5. RGD Strain RSO annotation pipeline RGD Automated Pipelines

Region

Damaging Variants
Number of Damaging Variants
SampleRnor_6.0Rnor_5.0RGSC_v3.4
DA/BklArbNsi (KNAW) 783
DA/BklArbNsi (ICAHN) 503


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_drgs_chems Females develop mammary tumors in 50-55 days when induced by 7,12 dimethybenz(alpha)anthracene (DMBA) 1599317
strain_other Trpv2 expression was 1.9 fold higher in fibroblast-like synoviocytes (FLS) which were isolated from the synovial tissue of DA as compared to the ones isolated from DA.F344-(D10Mit9-D10Rat24)/Nsi 9999444
strain_reproduction Good reproductive performance, average number weaned/female/week is 1.1 737882

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-10-14 DA/BklArbNsi    DA/BklArbNsi    Name updated 68913 APPROVED
2013-10-14 DA/BklArbNsi    DA/BklArbNsi    Name updated 68913 APPROVED
2013-10-14 DA/BklArbNsi    DA/BklArbNsi    Name updated 68913 APPROVED
2013-10-14 DA/BklArbNsi    DA/BklArbNsi    Name updated 68913 APPROVED

Database Acc Id Source(s)
RRRC RRRC:00693 RGD