Strain Report - Rat Genome Database

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Strain: WF.WKY-(D10Got124-D10Rat187)/Uwm

Symbol: WF.WKY-(D10Got124-D10Rat187)/Uwm
Strain: WF.WKY-(D10Got124-D10Rat187)
Substrain: Uwm
RGD ID: 1598797
Citation ID: RRID:RGD_1598797
Ontology ID: RS:0001583
Previously known as: WF.WKy-Mcs7; line D; WF.WKY-(D10Got124-D10Rat187)/Uwm
Type: congenic
Source: Department of Oncology, University of Wisconsin, Madison Wisconsin
Origin: WKY/NHsd females were bred with WF/NHsd males to generate F1 males which were backcrossed with WF/NHsd females. This contains 24.7 Mb region of Mcs7 QTL.
Last Known Status: Unknown
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21085,565,469 - 106,428,971RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.01088,544,136 - 110,355,174RGD_MAPPER_PIPELINERnor6.0
Rnor_5.01088,338,460 - 109,941,891RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.41089,575,059 - 110,385,665RGD_MAPPER_PIPELINERGSC3.4

Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype


References - curated
# Reference Title Reference Citation
1. The Mcs7 quantitative trait locus is associated with an increased susceptibility to mammary cancer in congenic rats and an allele-specific imbalance. Cotroneo MS, etal., Oncogene. 2006 Aug 17;25(36):5011-7. Epub 2006 Mar 27.
2. RGD Strain RSO annotation pipeline RGD Automated Pipelines


Position Markers

Flank 1 / 1 (D10Got124)
Rat AssemblyChrPosition (strand)Source
mRatBN7.21085,565,469 - 85,565,619 (+)MAPPER
mRatBN7.21085,565,469 - 85,565,684 (+)MAPPER
Rnor_6.01088,544,136 - 88,544,394NCBI
Rnor_6.01088,544,136 - 88,544,285NCBI
Rnor_5.01088,338,460 - 88,338,609UniSTS
Rnor_5.01088,338,460 - 88,338,718UniSTS
RGSC_v3.41089,575,060 - 89,575,209UniSTS
RGSC_v3.41089,575,059 - 89,575,209RGD
RGSC_v3.11089,589,430 - 89,589,579RGD
Celera1084,281,700 - 84,281,849UniSTS
RH 3.4 Map10838.5UniSTS
RH 3.4 Map10838.5RGD
RH 2.0 Map10966.6RGD
Cytogenetic Map10q32.1UniSTS

Flank 2 / 1 (D10Rat187)
Rat AssemblyChrPosition (strand)Source
mRatBN7.210106,428,724 - 106,428,971 (+)MAPPER
Rnor_6.010110,354,928 - 110,355,174NCBI
Rnor_5.010109,941,645 - 109,941,891UniSTS
RGSC_v3.410110,385,418 - 110,385,665RGD
RGSC_v3.410110,385,419 - 110,385,665UniSTS
RGSC_v3.110110,399,813 - 110,400,206RGD
Celera10104,967,315 - 104,967,561UniSTS
FHH x ACI Map1094.62RGD
FHH x ACI Map1094.62UniSTS
Strain QTL Data
Symbol Name Trait
Mcs15 Mammary carcinoma susceptibility QTL 15 mammary gland integrity trait   (VT:0010552)    

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_characteristics 50% higher tumor multiplicity when induced with DMBA 1581951
strain_other pattern of allelic imbalance was similar to parent WF 1581951