Strain Report - Rat Genome Database

Send us a Message



 Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap)  (beta) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer) Overgo Probe Designer
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease COVID-19 Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Poster Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Strain Registration

Strain: WF.WKY-(D10Got124-D10Rat187)/Uwm

Symbol: WF.WKY-(D10Got124-D10Rat187)/Uwm
Strain: WF.WKY-(D10Got124-D10Rat187)
Substrain: Uwm
RGD ID: 1598797
Citation ID: RRID:RGD_1598797
Ontology ID: RS:0001583
Previously known as: WF.WKy-Mcs7; line D; WF.WKY-(D10Got124-D10Rat187)/Uwm
Type: congenic
Source: Department of Oncology, University of Wisconsin, Madison Wisconsin
Origin: WKY/NHsd females were bred with WF/NHsd males to generate F1 males which were backcrossed with WF/NHsd females. This contains 24.7 Mb region of Mcs7 QTL.
Last Known Status: Unknown
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21085,565,469 - 106,428,971RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.01088,544,136 - 110,355,174RGD_MAPPER_PIPELINERnor6.0
Rnor_5.01088,338,460 - 109,941,891RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.41089,575,059 - 110,385,665RGD_MAPPER_PIPELINERGSC3.4





Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype

References

References - curated
# Reference Title Reference Citation
1. The Mcs7 quantitative trait locus is associated with an increased susceptibility to mammary cancer in congenic rats and an allele-specific imbalance. Cotroneo MS, etal., Oncogene. 2006 Aug 17;25(36):5011-7. Epub 2006 Mar 27.
2. RGD Strain RSO annotation pipeline RGD Automated Pipelines

Region

Position Markers

Flank 1 / 1 (D10Got124)
Rat AssemblyChrPosition (strand)Source
mRatBN7.21085,565,469 - 85,565,619 (+)MAPPER
mRatBN7.21085,565,469 - 85,565,684 (+)MAPPER
Rnor_6.01088,544,136 - 88,544,394NCBI
Rnor_6.01088,544,136 - 88,544,285NCBI
Rnor_5.01088,338,460 - 88,338,609UniSTS
Rnor_5.01088,338,460 - 88,338,718UniSTS
RGSC_v3.41089,575,060 - 89,575,209UniSTS
RGSC_v3.41089,575,059 - 89,575,209RGD
RGSC_v3.11089,589,430 - 89,589,579RGD
Celera1084,281,700 - 84,281,849UniSTS
RH 3.4 Map10838.5UniSTS
RH 3.4 Map10838.5RGD
RH 2.0 Map10966.6RGD
Cytogenetic Map10q32.1UniSTS

Flank 2 / 1 (D10Rat187)
Rat AssemblyChrPosition (strand)Source
mRatBN7.210106,428,724 - 106,428,971 (+)MAPPER
Rnor_6.010110,354,928 - 110,355,174NCBI
Rnor_5.010109,941,645 - 109,941,891UniSTS
RGSC_v3.410110,385,418 - 110,385,665RGD
RGSC_v3.410110,385,419 - 110,385,665UniSTS
RGSC_v3.110110,399,813 - 110,400,206RGD
Celera10104,967,315 - 104,967,561UniSTS
FHH x ACI Map1094.62RGD
FHH x ACI Map1094.62UniSTS
Strain QTL Data
Symbol Name Trait
Mcs15 Mammary carcinoma susceptibility QTL 15 mammary gland integrity trait   (VT:0010552)    

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_characteristics 50% higher tumor multiplicity when induced with DMBA 1581951
strain_other pattern of allelic imbalance was similar to parent WF 1581951