Strain Report - Rat Genome Database

Name: SR/JrHsd
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Strain Registration

General

Strain: SR/JrHsd
Symbol:	SR/JrHsd
Strain:	SR
Substrain:	JrHsd
Full Name:	Dahl Salt-Resistant
RGD ID:	1582184
Citation ID:	RRID:RGD_1582184
Ontology ID:	RS:0001454
Also known as:	Dahl R/hsd; MDC-03-83
Type:	inbred
Source:	Envigo
Origin:	Substrain of Dahl SR, from a Sprague-Dawley outbred colony, selected for resistance to salt-induced hypertension (Dahl, 1962), from Dr. John P. Rapp, Medical College of Ohio, Toledo,Ohio; to Harlan in 1986.
Coat Color:	Albino
Last Known Status:	Unknown

Annotation Click to see Annotation Detail View

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

decreased survivor rate (IAGP)

Phenotype Values via PhenoMiner Click to see Annotation Detail View

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Clinical Measurement

systolic blood pressure

diastolic blood pressure

mean arterial blood pressure

body weight

heart weight to body weight ratio

single kidney wet weight

both kidneys wet weight

plasma triglyceride level

plasma estradiol level

plasma total cholesterol level

percentage of experiment time spent in a discrete space in an experimental apparatus

distance moved per unit of time into, out of or within a discrete space in an experimental apparatus

uterus weight

average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus

difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase

glomerular filtration rate to kidney weight ratio

total horizontal distance resulting from voluntary locomotion in pursuit of a target in an experimental apparatus

References

References - curated


1.	Herrera VL, etal., Physiol Genomics. 2006 Aug 16;26(3):172-9. Epub 2006 May 23.
2.	Herrera VL, etal., PLoS One. 2012;7(8):e43160. doi: 10.1371/journal.pone.0043160. Epub 2012 Aug 17.
3.	Klemcke HG, etal., Shock. 2008 Jun;29(6):748-53.
4.	Personal communication with Harlan Laboratories
5.	RGD Automated Pipelines
6.	Ruiz-Opazo N and Tonkiss J, Physiol Genomics. 2004 Feb 13;16(3):329-33.
7.	Ruiz-Opazo N and Tonkiss J, Physiol Genomics. 2006 Jul 12;26(2):145-51.
8.	Saar K, etal., Nat Genet. 2008 May;40(5):560-6.

Region

Strain QTL Data

Symbol	Name	Trait
Bp287	Blood pressure QTL 287	arterial blood pressure trait (VT:2000000)
Bp288	Blood pressure QTL 288	arterial blood pressure trait (VT:2000000)
Bp289	Blood pressure QTL 289	arterial blood pressure trait (VT:2000000)
Bp290	Blood pressure QTL 290	arterial blood pressure trait (VT:2000000)
Bp291	Blood pressure QTL 291	arterial blood pressure trait (VT:2000000)
Bp292	Blood pressure QTL 292	arterial blood pressure trait (VT:2000000)
Bp293	Blood pressure QTL 293	arterial blood pressure trait (VT:2000000)
Bp294	Blood pressure QTL 294	arterial blood pressure trait (VT:2000000)
Bp295	Blood pressure QTL 295	arterial blood pressure trait (VT:2000000)
Bp296	Blood pressure QTL 296	arterial blood pressure trait (VT:2000000)
Bp297	Blood pressure QTL 297	arterial blood pressure trait (VT:2000000)
Bp387	Blood pressure QTL 387	arterial blood pressure trait (VT:2000000)
Bp388	Blood pressure QTL 388	arterial blood pressure trait (VT:2000000)
Bp389	Blood pressure QTL 389	arterial blood pressure trait (VT:2000000)
Bp390	Blood pressure QTL 390	arterial blood pressure trait (VT:2000000)
Bp391	Blood pressure QTL 391	arterial blood pressure trait (VT:2000000)
Cm61	Cardiac mass QTL 61	heart mass (VT:0007028)
Cm62	Cardiac mass QTL 62	heart mass (VT:0007028)
Cm63	Cardiac mass QTL 63	heart mass (VT:0007028)
Cm64	Cardiac mass QTL 64	heart mass (VT:0007028)
Cm65	Cardiac mass QTL 65	heart mass (VT:0007028)
Cm66	Cardiac mass QTL 66	heart mass (VT:0007028)
Glom10	Glomerulus QTL 10	kidney glomerulus morphology trait (VT:0005325)
Glom11	Glomerulus QTL 11	kidney glomerulus morphology trait (VT:0005325)
Glom12	Glomerulus QTL 12	kidney glomerulus morphology trait (VT:0005325)
Glom13	Glomerulus QTL 13	kidney glomerulus morphology trait (VT:0005325)
Glom14	Glomerulus QTL 14	kidney glomerulus morphology trait (VT:0005325)
Glom9	Glomerulus QTL 9	kidney glomerulus morphology trait (VT:0005325)
Mcs31	Mammary carcinoma susceptibility QTL 31	mammary gland integrity trait (VT:0010552)
Mcs32	Mammary carcinoma susceptibility QTL 32	mammary gland integrity trait (VT:0010552)
Mcs33	Mammary carcinoma susceptibility QTL 33	mammary gland integrity trait (VT:0010552)
Mcs34	Mammary carcinoma susceptibility QTL 34	mammary gland integrity trait (VT:0010552)
Memor1	Memory QTL 1	exploratory behavior trait (VT:0010471)
Memor10	Memory QTL 10	exploratory behavior trait (VT:0010471)
Memor11	Memory QTL 11	exploratory behavior trait (VT:0010471)
Memor12	Memory QTL 12	exploratory behavior trait (VT:0010471)
Memor13	Memory QTL 13	exploratory behavior trait (VT:0010471)
Memor14	Memory QTL 14	exploratory behavior trait (VT:0010471)
Memor15	Memory QTL 15	exploratory behavior trait (VT:0010471)
Memor16	Memory QTL 16	exploratory behavior trait (VT:0010471)
Memor17	Memory QTL 17	exploratory behavior trait (VT:0010471)
Memor2	Memory QTL 2	exploratory behavior trait (VT:0010471)
Memor3	Memory QTL 3	exploratory behavior trait (VT:0010471)
Memor4	Memory QTL 4	exploratory behavior trait (VT:0010471)
Memor5	Memory QTL 5	exploratory behavior trait (VT:0010471)
Memor6	Memory QTL 6	exploratory behavior trait (VT:0010471)
Memor7	Memory QTL 7	exploratory behavior trait (VT:0010471)
Memor8	Memory QTL 8	exploratory behavior trait (VT:0010471)
Memor9	Memory QTL 9	exploratory behavior trait (VT:0010471)
Scl54	Serum cholesterol level QTL 54	blood cholesterol amount (VT:0000180)
Scl55	Serum cholesterol level QTL 55	blood cholesterol amount (VT:0000180)
Scl56	Serum cholesterol level QTL 56	blood cholesterol amount (VT:0000180)
Scl57	Serum cholesterol level QTL 57	blood cholesterol amount (VT:0000180)
Scl58	Serum cholesterol level QTL 58	blood cholesterol amount (VT:0000180)

Damaging Variants

	Number of Damaging Variants
Sample	Rnor_6.0	Rnor_5.0	RGSC_v3.4
SR/JrHsd (MCW)			1299
SR/JrHsd (ICL)			631
SR/JrHsd (MCW)		1665
SR/JrHsd (KNAW)		726
SR/JrHsd (MCW)	3031
SR/JrHsd (RGD)	1071
SR/JrHsd (2020)	2596
SR/JrHsd (2020)

Additional Information

RGD Curation Notes

Note Type	Note	Reference
strain_other	These have significantly better acquisition and spatial accuracy performance than SS/JrHsd	1581615
strain_other	These have shorter survival time after controlled hemorrhage than BN/HsdMcwiCrl but longer than DA/OlaHsd.	2302114

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Strain: SR/JrHsd

Related Phenotype Data for Term "SR/JrHsd" (RS:0001454)