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Strain: T2DN/Mcwi

Symbol: T2DN/Mcwi
Strain: T2DN
Substrain: Mcwi
RGD ID: 1579693
RRID: RGD_1579693
Ontology ID: RS:0001576
Also known as: MDC-03-10
Type: inbred
Source: Department of Physiology, Medical College of Wisconsin, Milwaukee Wisconsin
Origin: Generated by crossing GK/Swe with female FHH/EurMcwi. During the F1 studies, the GK/Swe started to die out. In order to preserve the GK strain, single male GK was serially crossed to the ongoing GK-FHH cross. This resulted in rapid fixation of the original GK genome except for mitochondrial DNA. In the sixth generation male and female T2DN were intercrossed and strict b x s mating was maintained.
Last Known Status: Unknown

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Additional Information

RGD Curation Notes
Note Type Note Reference
strain_characteristics These are 97% genetically identical to GK/Far, 1% difference is accounted for the FHH genome retained in these animals. 1303373
strain_life_disease Exhibits proteinuria by 6 months of age along with renal histologic abnormalities like focal glomerulosclerosis, mesengial matrix expansion and thickening of the basement membranes. 1303373
strain_other The major difference between these and the GK rats is on chr 1 with five polymorphism clustered in 57-cM segment suggesting that the common progenitor carried different haplotype in this segment which is linked to Niddm 7 QTL which is on this segment in GK rats. 1303373
strain_phys_biochem Good model for diabetic nephropathy; no significant difference in fasting glucose level is observed between these and the GK rats; exhibit glomerular hypertrophy which is evident in GK rats. 1303373