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Strain Registration

Strain: SD-Mecp2em1Sage/Hsd

Symbol: SD-Mecp2em1Sage/Hsd
Strain: SD-Mecp2em1
Substrain: SageHsd
RGD ID: 156430169
Citation ID: RRID:RGD_156430169
Ontology ID: RS:0005254
Also Known As: SD-Mecp2^[em1Sage]/Hsd
Type: mutant
Available Source: ENVIGO
Origination: ENVIGO
Description: The MeCP2 KO rat model was originally created at SAGE Labs, Inc. in St. Louis, MO and distributed out of the Boyertown, PA facility. The line continues to be maintained through the original SAGE Labs animal inventory acquired by Envigo. The ZFN mutant rat strain was produced by injecting zinc finger nuclease targeting rat Mecp2 into Sprague Dawley embryos. This mutant rat has a knockout of the methyl CpG binding protein 2 (Mecp2).
Genetic Status: Heterozygous
Last Known Status: Cryopreserved Embryo (as of 2023-02-22)
Research Usage Autism, Rett syndrome, Cognition






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