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Strain Registration

Strain: MV/Opu

Symbol: MV/Opu
Strain: MV
Substrain: Opu
Full Name: myelin vacuolation rat
RGD ID: 1559043
Citation ID: RRID:RGD_1559043
Ontology ID: RS:0001372
Alleles: Atrnmv
Previously known as: MV; NBRP Rat No: 0100
Type: mutant
Source: National BioResource Project for the Rat in Japan
Origin: The myelin vacuolation rats showing body tremor were found in an outbred colony of Sprague-Dawley rats at Osaka Osaka Prefecture University in 1999.
Coat Color: Albino
Last Known Status: Cryopreserved Embryo; Cryopreserved Sperm
Research Usage Neurobiology
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23118,110,320 - 118,244,326RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.03123,434,409 - 123,567,922RGD_MAPPER_PIPELINERnor6.0
Rnor_5.03129,934,303 - 130,067,267RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.43118,539,268 - 118,701,177RGD_MAPPER_PIPELINERGSC3.4





Disease Annotations     Click to see Annotation Detail View
Tremor  (IAGP)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype

Phenotype Values via PhenoMiner     Click to see Annotation Detail View
Options:  View chart  |  Download data table  |  View expanded data table

Clinical Measurement
heart rate
systolic blood pressure
body weight
body temperature
red blood cell count
blood hemoglobin level
white blood cell count
platelet count
hematocrit
mean corpuscular volume
plasma glucose level
plasma aspartate aminotransferase activity level
plasma alanine aminotransferase activity level
plasma alkaline phosphatase activity level
plasma total protein level
plasma albumin level
plasma phosphate level
plasma chloride level
plasma sodium level
plasma potassium level
heart wet weight
heart weight to body weight ratio
both kidneys wet weight
lung wet weight
urine potassium level
urine sodium level
brain weight to body weight ratio
both kidneys wet weight as percentage of body weight
liver weight as percentage of body weight
spleen weight to body weight ratio
brain wet weight
lung weight to body weight ratio
liver wet weight
both adrenal glands wet weight
spleen wet weight
both testes wet weight
activated partial thromboplastin time
prothrombin time
timed urine volume
mean corpuscular hemoglobin
mean corpuscular hemoglobin concentration
blood basophil count to total leukocyte count ratio
blood eosinophil count to total leukocyte count ratio
blood lymphocyte count to total leukocyte count ratio
blood monocyte count to total leukocyte count ratio
total plasma calcium level
urine chloride level
plasma creatinine level
plasma triglyceride level
plasma total cholesterol level
plasma urea nitrogen level
both adrenal glands weight to body weight ratio
plasma high density lipoprotein cholesterol level
plasma low density lipoprotein cholesterol level
both testes wet weight to body weight ratio
urine sodium excretion rate to body weight ratio
timed urine volume to body weight ratio
urine chloride excretion rate to body weight ratio
urine potassium excretion rate to body weight ratio
plasma total bilirubin level
blood segmented neutrophil count to total leukocyte count ratio
blood band neutrophil count to total leukocyte count ratio
non-specified leukocyte count to total leukocyte count ratio
plasma albumin to plasma total protein ratio

References

References - curated
# Reference Title Reference Citation
1. The myelin vacuolation (mv) rat with a null mutation in the attractin gene. Kuwamura M, etal., Lab Invest 2002 Oct;82(10):1279-86.
2. Strains registered by the National Bio Resource Project for the Rat in Japan Personal Communication with NBRP
3. RGD Strain RSO annotation pipeline RGD Automated Pipelines
4. PCR-based genotyping of the rat Atrn(mv) mutation. Tokuda S, etal., Exp Anim 2004 Jan;53(1):73-6.

Region


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_behavior The tremor behavior was exhibited from around 3 weeks of age and inherited as an autosomal recessive trait. 1299186
strain_other Linkage analysis using intercross progeny between the myelin vacuolation (mv) rat, named after the pathologic characteristics, and normal control rat strains showed that the mv phenotypes were cosegregated with polymorphic markers adjacent to the Atrn (Attractin, formerly zi [zitter]) locus on rat chromosome 3 1299186
strain_other A test for allelism suggested that the mv mutation was a new allele in Atrn: In comparison with a marked decrease of Atrn(zi)/Arn(zi), Northern blot analysis revealed no expression of Atrn mRNA in the brain of the mv rats. Finally, a genomic deletion including exon 1 of the mv rats was detected by genomic and sequence analyses. Discovery of the rat null mutation Atrn(mv), different from Atrn(zi), provides a new animal model for studying the functions of the attractin protein. 1299186
strain_phys_biochem The mutant rats had variously sized vacuoles in the neuropil and white matter throughout the central nervous system, especially in the brain stem, cerebellum, and spinal cord. Ultrastructurally these vacuoles mainly consisted of splitting of myelin lamella both in the periaxonal and intermyelinic spaces. 1299186
strain_reproduction Although affected rats are fertile for both sexes, it is recommended to use heterozygous males and females for mating. 1299186