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Strain: LEC-Tg(ATP7B)Tohm

Symbol: LEC-Tg(ATP7B)Tohm
Strain: LEC-Tg(ATP7B)
Substrain: Tohm
RGD ID: 1559030
Citation ID: RRID:RGD_1559030
Ontology ID: RS:0001347
Also Known As: LEC(LECSDF1)-Tg(hATP7B)Tohm; NBRP Rat No: 0216
Type: transgenic
Available Source: National BioResource Project for the Rat in Japan
Origination: National BioResource Project for the Rat in Japan
Description: A 4.5 kb fragment of human ATP7B cDNA was blunt-end ligated into the pCXN2 vector that contained the CAG promoter to generate pCXN2ATP7B which was microinjected into the pronuclei of LEC/Crlj. The transgenic founders were identified by the PCR analysis of the tail-DNA.
Inbred Generations: F5
Last Known Status: Cryopreserved Embryo; Cryopreserved Sperm
Research Usage Cancer





References

References - curated
# Reference Title Reference Citation
1. Restoration of copper metabolism and rescue of hepatic abnormalities in LEC rats, an animal model of Wilson disease, by expression of human ATP7B gene. Meng Y, etal., Biochim Biophys Acta 2004 Nov 5;1690(3):208-19.
2. Strains registered by the National Bio Resource Project for the Rat in Japan Personal Communication with NBRP
3. RGD Strain RSO annotation pipeline RGD Automated Pipelines

Region


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_life_disease These animals showed significant rescue from hepatitis which includes suppression of hepatocellular carcinoma and late onset of hepatic cholangiofibrosis. 1554300
strain_phys_biochem Expression of ATP7B in the liver of the transgenic rats restored the biosynthesis of holoceruloplasmin and biliary copper excretion. 1554300

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-05-10 LEC-Tg(ATP7B)Tohm    LEC-Tg(ATP7B)Tohm    Name updated 68913 APPROVED
2012-05-10 LEC-Tg(ATP7B)Tohm    LEC-Tg(ATP7B)Tohm    Name updated 68913 APPROVED