Strain Report - Rat Genome Database
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Strain: GAERS/Mave

Symbol: GAERS/Mave
Strain: GAERS
Substrain: Mave
Full Name: Genetic Absence Epilepsy Rats from Strasbourg
RGD ID: 1554304
RRID: RGD_1554304
Ontology ID: RS:0000481
Also known as: GAERS; GAERS/Mave;NBRP Rat No: 0285; MDC-01-74; GAERS/Ins
Type: inbred
Source: National BioResource Project for the Rat in Japan
Origin: 30% of the Wistar rats from the initial breeding colony in Strasbourg had spontaneous spike and wave discharges (SWDs) which were bilateral and synchronous over the cerebral cortex. Breeders with SWDs were selected and used for breeding.
Coat Color: Albino
Inbred Generations: F37
Last Known Status: Cryopreserved Embryo; Cryopreserved Sperm
Research Usage Neurobiology






Phenotype Values via PhenoMiner     Click to see Annotation Detail View
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Clinical Measurement
heart rate
systolic blood pressure
body weight
body temperature
red blood cell count
blood hemoglobin level
white blood cell count
platelet count
hematocrit
mean corpuscular volume
plasma glucose level
plasma aspartate aminotransferase activity level
plasma alanine aminotransferase activity level
plasma alkaline phosphatase activity level
plasma total protein level
plasma albumin level
plasma phosphate level
plasma chloride level
plasma sodium level
plasma potassium level
heart wet weight
heart weight to body weight ratio
both kidneys wet weight
lung wet weight
urine potassium level
urine sodium level
brain weight to body weight ratio
both kidneys wet weight as percentage of body weight
liver weight as percentage of body weight
spleen weight to body weight ratio
brain wet weight
lung weight to body weight ratio
liver wet weight
both adrenal glands wet weight
spleen wet weight
both testes wet weight
activated partial thromboplastin time
prothrombin time
timed urine volume
mean corpuscular hemoglobin level
mean corpuscular hemoglobin concentration
blood basophil count to total leukocyte count ratio
blood eosinophil count to total leukocyte count ratio
blood lymphocyte count to total leukocyte count ratio
blood monocyte count to total leukocyte count ratio
total plasma calcium level
urine chloride level
plasma creatinine level
plasma triglyceride level
plasma total cholesterol level
plasma urea nitrogen level
both adrenal glands weight to body weight ratio
plasma high density lipoprotein cholesterol level
plasma low density lipoprotein cholesterol level
both testes wet weight to body weight ratio
brain spike-and-wave discharge rate
brain total spike-and-wave discharge duration
brain spike-and-wave discharge amplitude
brain spike-and-wave discharge frequency
urine sodium excretion rate to body weight ratio
timed urine volume to body weight ratio
urine chloride excretion rate to body weight ratio
urine potassium excretion rate to body weight ratio
total plasma bilirubin level
blood segmented neutrophil count to total leukocyte count ratio
blood band neutrophil count to total leukocyte count ratio
non-specified leukocyte count to total leukocyte count ratio
plasma albumin to plasma total protein ratio

References


Region

Strain QTL Data
Symbol Name Trait
Swd3 Spike wave discharge measurement QTL 3 brain electrophysiology trait   (VT:0010557)    
Swd4 Spike wave discharge measurement QTL 4 brain electrophysiology trait   (VT:0010557)    
Swd5 Spike wave discharge measurement QTL 5 brain electrophysiology trait   (VT:0010557)    

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_drgs_chems Spike and wave discharges can be suppressed by antiepileptic drugs (AEDs). 1553898
strain_life_disease On average, spike and wave discharges occur 1.3 times/min and lasts approximately 17 seconds. 1553898
strain_life_disease SWDs start and end abruptly and their voltage varies from 300-1000 microvolts. 1553897
strain_other Model for idiopathic generalized epilepsy which develops EEG paroxysms spontaneously. 1553898
strain_reproduction Good breeding performance 1553897

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-05-16 GAERS/Mave  Genetic Absence Epilepsy Rats from Strasbourg  GAERS/Mave  Genetic Absence Epilepsy Rats from Strasbourg  Name updated 68913 APPROVED