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Strain: CVD/Opu

Symbol: CVD/Opu
Strain: CVD
Substrain: Opu
Full Name: Cerebellar vermis defect rat
RGD ID: 1554303
Citation ID: RRID:RGD_1554303
Ontology ID: RS:0000469
Alleles: Unc5c
Type: mutant
Source: Department of Veterinary Pathology, Osaka Prefecture University, Sakai, Osaka, Japan
Origin: Originated from a colony of Lewis rats that were spontaneously ataxic. Maintained by brother-sister mating with phenotypically normal littermates.
Last Known Status: Unknown
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22230,180,353 - 230,535,219RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.02247,045,813 - 247,397,483RGD_MAPPER_PIPELINERnor6.0
Rnor_5.02265,573,406 - 265,926,229RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.42239,365,109 - 239,721,231RGD_MAPPER_PIPELINERGSC3.4






References


Region


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_anatomy Perivascular aggregation of external granule cells (EGCs) is observed during postnatal cerebellar development. 1302460
strain_characteristics They have fused cerebellar hemisphere which leads to cerebellar vermis defects and dysplasia in the cerebellum. 1302460
strain_life_disease From 14 days of age they develop hind-leg paralysis leading to heriditary cerebellar vermis defect. 1553899
strain_life_disease Predicted to have truncated Unc5c protein that is expressed in the brain. 1302733
strain_other These are neurological mutant rats that are used as a model for the pathogenesis of cerebellar vermis defect (CVD) due to genetic insults. 1302460