This HS is maintained and distributed from Dr. Palmer's laboratory at UCSD. The origin of HS was from 25 breeding pairs obtained from Dr. Eva Redei, Northwestern University (Chicago) at 55 breeding generations; these animals exhibit 30% genome-wide heterozygosity which is maintained by using a rotational breeding strategy. The Wake Forest HS rats were derived from NMcwi:HS at the Medical College of Wisconsin and maintained at Wake Forest Baptist Medical Center starting in 2017. The colony from Wake Forest was sent to Dr. Palmer's laboratory at University of California San Diego
Department of Psychiatry.