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Strain Registration

Strain: SD-Cftrem1Apb

Symbol: SD-Cftrem1Apb
Strain: SD-Cftrem1
Substrain: Apb
RGD ID: 151356958
Citation ID: RRID:RGD_151356958
Ontology ID: RS:0005134
Alleles: Cftrem1Apb
Previously known as: Phe508del
Type: mutant
Source: Organization: Australian Phenomics Facility, Australian National University
Origin: The CRISPR/Cas9 system was used to target exon 11 to create a deletion at codon F508 which was injected into Sprague-Dawley one-cell embryos (C076 line). One rat had an allele that contained the desired homology-directed repair edited TTT deletion and was designated the Phe508del founder (c.1522_1524delTTT).
Genetic Status: Homozygous
Last Known Status: Unknown





Phenotype Values via Phenominer Click to see Annotation Detail View

Related Phenotype Data for Term "SD-Cftrem1Apb" (RS:0005134)

Rat Strains:
Clinical Measurements:
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Measurement Methods:
References

References - curated
# Reference Title Reference Citation
1. Phenotypic Characterization and Comparison of Cystic Fibrosis Rat Models Generated Using CRISPR/Cas9 Gene Editing. McCarron A, etal., Am J Pathol. 2020 May;190(5):977-993. doi: 10.1016/j.ajpath.2020.01.009. Epub 2020 Feb 18.

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