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Strain Registration

Strain: SD-Ddah1em1Ywxu

Symbol: SD-Ddah1em1Ywxu
Strain: SD-Ddah1em1
Substrain: Ywxu
RGD ID: 151347605
Citation ID: RRID:RGD_151347605
Ontology ID: RS:0005128
Alleles: Ddah1em1Ywxu
Also Known As: DDAH1-/-; DDAH1 knockout; SD-Ddah1^[em1Ywxu]
Type: mutant
Available Source: Not Available
Origination: Cardiovascular Department, Shanghai Tenth People's Hospital, Tongji University, School of Medicine, Shanghai, China
Description: CRISPR-Cas9 technique was used to generate DDAH1-/- rats on Sprague-Dawley background. Genome deletion in exon 1 was confirmed by PCR analysis with the primers:DDAH1-F (5'-GCGCTGCTCTCGGGAAGA-3') and DDAH1-R (5'-GGGTGATGAGGGCGGTCT-3').
Genetic Status: Homozygous
Last Known Status: Unknown
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22234,667,499 - 234,800,322RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.02251,634,368 - 251,766,009RGD_MAPPER_PIPELINERnor6.0
Rnor_5.02270,160,842 - 270,289,319RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.42243,932,221 - 244,069,832RGD_MAPPER_PIPELINERGSC3.4





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Mammalian Phenotype

References

References - curated
# Reference Title Reference Citation
1. Dimethylarginine dimethylaminohydrolase 1 deficiency aggravates monocrotaline-induced pulmonary oxidative stress, pulmonary arterial hypertension and right heart failure in rats. Wang D, etal., Int J Cardiol. 2019 Nov 15;295:14-20. doi: 10.1016/j.ijcard.2019.07.078. Epub 2019 Jul 27.

Region


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