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Strain Registration

Strain: SD-Trpm4em1Sage

Symbol: SD-Trpm4em1Sage
Strain: SD-Trpm4em1
Substrain: Sage
RGD ID: 150521556
Citation ID: RRID:RGD_150521556
Ontology ID: N/A
Type: mutant
Source: Laboratory of Biological Psychology, Brain and Cognition, Katholieke Universiteit Leuven (KUL), Tiensestraat 102, 3000 Leuven, Belgium
Origin: Trpm4 gene specific Zinc finger constructs directed against exons 18-19, which contain the coding sequence for TM3-5 and the pore region of the TRPM4 protein, were injected in zygotes from Sprague-Dawley rats. This mutant rat with a 514 bp deletion which includes completely removes exon 18 and a piece of exon 19 from the Trpm4 gene, plus the intron 18-19. The deletion was confirmed via genomic sequencing and western blotting.
Genetic Status: Homozygous
Last Known Status: Unknown





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Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Disentangling the role of TRPM4 in hippocampus-dependent plasticity and learning: an electrophysiological, behavioral and FMRI approach. Bovet-Carmona M, etal., Brain Struct Funct. 2018 Nov;223(8):3557-3576. doi: 10.1007/s00429-018-1706-1. Epub 2018 Jul 3.
2. Low frequency pulse stimulation of Schaffer collaterals in Trpm4-/- knockout rats differently affects baseline BOLD signals in target regions of the right hippocampus but not BOLD responses at the site of stimulation. Bovet-Carmona M, etal., Neuroimage. 2019 Mar;188:347-356. doi: 10.1016/j.neuroimage.2018.12.020. Epub 2018 Dec 13.

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