Strain Report - Rat Genome Database

Name: SHR- Gja8 m1+/-Cub
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Strain Registration

General

Strain: SHR-Gja8^m1+/-Cub

Symbol:

SHR-Gja8^m1+/-Cub

Strain:

SHR-Gja8^m1+/-

Substrain:

Cub

RGD ID:

150520205

Citation ID:

RRID:RGD_150520205

Ontology ID:

RS:0005077

Alleles:

Gja8^m1Cub

Also Known As:

SHR-Dca+/-; SHR-Gja8^[m1+/-Cub]

Type:

mutant

Available Source:

Not Available

Origination:

Department of Biology, Charles University in Prague, Prague, Czech Republic

Description:

This strain is derived from SHR/OlaIpcv where a spontaneous mutation was observed in the NH₂-terminal cytosolic domain of Cx50, L7Q. The connexin50 mutation in heterozygous state affects significantly the lipid profile and the oxidative stress parameters in SHR rats.

Genetic Status:

Heterozygous

Last Known Status:

Unknown

Position

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	184,492,360 - 184,492,360	RGD_MAPPER_PIPELINE	mRatBN7.2
Rnor_6.0	2	199,052,374 - 199,052,374	RGD_MAPPER_PIPELINE	Rnor6.0
Rnor_5.0	2	218,536,831 - 218,538,447	RGD_MAPPER_PIPELINE	Rnor5.0

Mutant Strains

SHR-Gja8m1-/-Cub

Annotation Click to see Annotation Detail View

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

decreased circulating HDL cholesterol level (IAGP)

decreased circulating LDL cholesterol level (IAGP)

decreased fasting circulating glucose level (IAGP)

decreased glutathione level (IAGP)

decreased glutathione peroxidase activity (IAGP)

decreased glutathione reductase level (IAGP)

decreased superoxide dismutase level (IAGP)

hyperchylomicronemia (IAGP)

increased catalase level (IAGP)

increased circulating CCL3 level (IAGP)

increased circulating insulin level (IAGP)

increased circulating interleukin-17 level (IAGP)

increased circulating triglyceride level (IAGP)

increased circulating tumor necrosis factor level (IAGP)

increased epididymal fat pad weight (IAGP)

increased interleukin-12 secretion (IAGP)

increased interleukin-18 secretion (IAGP)

increased interleukin-6 secretion (IAGP)

References

References - curated

#	Reference Title	Reference Citation
1.	Heterozygous connexin 50 mutation affects metabolic syndrome attributes in spontaneously hypertensive rat.	Šeda O, etal., Lipids Health Dis. 2016 Nov 21;15(1):199. doi: 10.1186/s12944-016-0376-3.

Region

Additional Information

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Strain: SHR-Gja8m1+/-Cub

Mammalian Phenotype

Strain: SHR-Gja8^m1+/-Cub