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Strain: Wpk

Symbol: Wpk
Strain: Wpk
Full Name: Wistar polycystic kidney rat
RGD ID: 14995941
Citation ID: RRID:RGD_14995941
Ontology ID: RS:0004763
Alleles: Tmem67wpk
Type: mutant
Source: Not Available
Origin: The wpk mutation was first recognized in 1994 in a colony of outbred Wistar rats at Utrecht University (Utrecht, The Netherlands). In 1996, a breeding pair of test-proven heterozygotes were transferred to the University of Rotterdam (Rotterdam, The Netherlands), and a new subcolony was initiated. This colony has been maintained by brother-sister matings for more than five generations. Individuals heterozygous for the mutant allele were identified in each generation by test-crossing phenotypically normal offspring from known heterozygotes. A single C to T substitution in exon 12 was identified as the mutated allele in the Wpk rat. This mutation converts a proline to a leucine in the protein products(P394L). This mutation was not present in the parental Wistar strain.
Last Known Status: Unknown
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2525,536,458 - 25,589,378RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.0525,666,138 - 25,721,056RGD_MAPPER_PIPELINERnor6.0
Rnor_5.0530,371,964 - 30,424,943RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.4526,324,625 - 26,377,531RGD_MAPPER_PIPELINERGSC3.4

Mutant Strains
Wpk +/-
Wpk -/-

Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype


References - curated
# Reference Title Reference Citation
1. Development of multiorgan pathology in the wpk rat model of polycystic kidney disease. Gattone VH, etal., Anat Rec A Discov Mol Cell Evol Biol. 2004 Apr;277(2):384-95. doi: 10.1002/ar.a.20022.
2. New rat model that phenotypically resembles autosomal recessive polycystic kidney disease. Nauta J, etal., J Am Soc Nephrol 2000 Dec;11(12):2272-84.
3. Hydrocephalus in a rat model of Meckel Gruber syndrome with a TMEM67 mutation. Shim JW, etal., Sci Rep. 2019 Jan 31;9(1):1069. doi: 10.1038/s41598-018-37620-5.
4. The transmembrane protein meckelin (MKS3) is mutated in Meckel-Gruber syndrome and the wpk rat. Smith UM, etal., Nat Genet. 2006 Feb;38(2):191-6. Epub 2006 Jan 15.


Allelic Variants
Name Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Assembly
Tmem67wpk-var1 chr5 25567678 25567678 C T C_to_T_transition mRatBN7.2

Additional Information