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Strain Registration

Strain: LE-Gad2em24Yyan

Symbol: LE-Gad2em24Yyan
Strain: LE-Gad2em24
Substrain: Yyan
RGD ID: 149735562
Citation ID: RRID:RGD_149735562
Ontology ID: RS:0005000
Alleles: Gad2em24Yyan
Also Known As: NBRP Rat No: 0907; LE-Gad2^[em24Yyan]
Type: mutant
Available Source: National BioResource Project for the Rat in Japan
Origination: Gunma University Graduate School of Medicine
Description: Knockout rats in which the Gad2 gene was disrupted using the TALEN. In this strain, the Gad2 gene encoding GAD65 was knocked out. In homozygous rats, a high rate of epileptic seizures was observed at 2 to 3 weeks of age.
Coat Color: Black hood
Inbred Generations: over F3
Last Known Status: Cryopreserved Sperm (as of 2021-07-22)
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81789,671,718 - 89,734,246RGD_MAPPER_PIPELINE
mRatBN7.21784,763,740 - 84,764,054RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.01789,171,576 - 89,234,770RGD_MAPPER_PIPELINERnor6.0
Rnor_5.01790,851,699 - 90,914,893RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.41796,259,430 - 96,321,857RGD_MAPPER_PIPELINERGSC3.4






References

References - curated
# Reference Title Reference Citation
1. Impact of GAD65 and/or GAD67 deficiency on perinatal development in rats. Jiang W, etal., FASEB J. 2022 Feb;36(2):e22123. doi: 10.1096/fj.202101389R.
2. Strains registered by the National Bio Resource Project for the Rat in Japan Personal Communication with NBRP

Region

Allelic Variants
Name Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Assembly
Gad2em24Yyan-var1 chr17 84763740 84764054 CTGAAGATGGCTCTGGGGATCCTGAGAACCCGGGAACAGGTAGGAAAACCAGAACCTGCAGCGGGAGAGCTTTGTGGA TGGATTAGGGTTTGCCCGGCTACGCAGATGATCAAAGCTTTGACATCTGCAACAGGAAACTTATTCAGGCGCTTCGCC TGGCTCCCTGGGTTAAGTCCTTAACTGTGCGAGAACCCCAACCCCTCCCCTCAGCCCTTTGTCCCCCTGGGAAAAAGC CCAGGGTTGTCTCGGCCCCTTCCCCTAAACGTAGGTTCCTAAAAGACTGCTGCATCTGCTGTCATCGGAAACCTGAGC TTT G delins mRatBN7.2

Additional Information