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Strain Registration

Strain: SD-Ahrem2Sage

Symbol: SD-Ahrem2Sage
Strain: SD-Ahrem2
Substrain: Sage
RGD ID: 13838845
Citation ID: RRID:RGD_13838845
Ontology ID: RS:0004674
Alleles: Ahrem2Sage
Also Known As: SD-Ahr^[em2Sage]
Type: mutant
Available Source: Not Available
Description: ZFN constructs were designed to target exon 2 which contains the DNA binding bHLH motif of the AHR gene.This ZFN model contains a 29-bp deletion in the rat Ahr gene.
Genetic Status: Homozygous
Last Known Status: Unknown
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8657,961,423 - 57,998,901RGD_MAPPER_PIPELINE
mRatBN7.2652,234,089 - 52,271,568RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.0654,963,990 - 55,001,806RGD_MAPPER_PIPELINERnor6.0
Rnor_5.0664,589,066 - 64,624,078RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.4654,205,104 - 54,240,268RGD_MAPPER_PIPELINERGSC3.4





Phenotype Annotations     Click to see Annotation Detail View

References

References - curated
# Reference Title Reference Citation
1. Knockout of the aryl hydrocarbon receptor results in distinct hepatic and renal phenotypes in rats and mice. Harrill JA, etal., Toxicol Appl Pharmacol. 2013 Oct 15;272(2):503-18. doi: 10.1016/j.taap.2013.06.024. Epub 2013 Jul 13.
2. Role of Glucocorticoid Receptor and Pregnane X Receptor in Dexamethasone Induction of Rat Hepatic Aryl Hydrocarbon Receptor Nuclear Translocator and NADPH-Cytochrome P450 Oxidoreductase. Hunter SR, etal., Drug Metab Dispos. 2017 Feb;45(2):118-129. doi: 10.1124/dmd.116.073833. Epub 2016 Nov 16.
3. Aryl hydrocarbon receptor is indispensable for β-naphthoflavone-induced novel food avoidance and may be involved in LiCl-triggered conditioned taste aversion in rats. Pohjanvirta R and Mahiout S, Physiol Behav. 2019 May 15;204:58-64. doi: 10.1016/j.physbeh.2019.02.014. Epub 2019 Feb 12.

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