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Strain: SD-Lepem1Sage+/+

Symbol: SD-Lepem1Sage+/+
Strain: SD-Lepem1+/Lepem1+
Substrain: Sage
RGD ID: 13792575
Citation ID: RRID:RGD_13792575
Ontology ID: RS:0004621
Also Known As: SD-Lep^[em1Sage+/+]
Type: mutant
Available Source: Not Available
Description: These wild type rats are littermates of homozygous knockout rats from heterozygote matings. The Lepr knockout model possesses a 151 bp deletion spanning the exon 1/intron 1 junction of the Leptin gene. Homozygous knockout rats display loss of Leptin protein via Western blot. Homozygous knockout rats demonstrate significant weight gain compared to wild type littermates. Homozygous knockout rats show significantly elevated serum cholesterol levels
Genetic Status: Wild Type
Last Known Status: Unknown (as of 2018-09-13)
Research Usage Cardiovascular





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