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Strain: SD-Cacna1f csnb

Symbol: SD-Cacna1f csnb
Strain: SD-Cacna1fcsnb
Full Name: congenital stationary night blindness rat
RGD ID: 13782371
Citation ID: RRID:RGD_13782371
Ontology ID: RS:0004615
Alleles: Cacna1f csnb
Also Known As: SD-Cacna1f ^[csnb]
Type: mutant
Available Source: Not Available
Description: A naturally-occurring mutation in Cacna1f was identified in a male Sprague Dawley rat with the phenotype of congenital stationary night blindness.Sequence analysis revealed a point mutation of C to T at position 2941, which changes codon 981 from arginine (CGA) to a stop codon (TGA). This R981Stop point mutation was predicted to lead to a version of protein shortened by a total of 999 amino acids, and missing the C-terminal and, in particular, part of the third and all of the fourth ion transport domains.
Last Known Status: Unknown
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X14,868,096 - 14,896,413RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.0X15,712,709 - 15,741,135RGD_MAPPER_PIPELINERnor6.0
Rnor_5.0X16,504,174 - 16,532,670RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.4X26,908,850 - 26,937,165RGD_MAPPER_PIPELINERGSC3.4





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References

References - curated
# Reference Title Reference Citation
1. Cacna1f gene decreased contractility of skeletal muscle in rat model with congenital stationary night blindness. An J, etal., Gene. 2015 May 15;562(2):210-9. doi: 10.1016/j.gene.2015.02.073. Epub 2015 Mar 4.
2. Behavioral phenotypic properties of a natural occurring rat model of congenital stationary night blindness with Cacna1f mutation. An J, etal., J Neurogenet. 2012 Sep;26(3-4):363-73. doi: 10.3109/01677063.2012.684416. Epub 2012 Jul 16.
3. A naturally-occurring mutation in Cacna1f in a rat model of congenital stationary night blindness. Gu Y, etal., Mol Vis. 2008 Jan 9;14:20-8.
4. Visual signal pathway reorganization in the Cacna1f mutant rat model. Tao Y, etal., Invest Ophthalmol Vis Sci. 2013 Mar 19;54(3):1988-97. doi: 10.1167/iovs.12-10706.
5. Retinal horizontal cells reduced in a rat model of congenital stationary night blindness. Zheng L, etal., Neurosci Lett. 2012 Jul 11;521(1):26-30. doi: 10.1016/j.neulet.2012.05.049. Epub 2012 May 24.

Region


Additional Information


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-09-07 SD-Cacna1f csnb  congenital stationary night blindness rat  SD-Cacna1f csnb    Name updated 68913 APPROVED
2018-09-07 SD-Cacna1f csnb    SD-Cacna1f csnb  calcium voltage-gated channel subunit alpha1 F; congenital stationary night blindness mutant  Name updated 68913 APPROVED
2018-09-07 SD-Cacna1f csnb    SD-Cacna1f csnb  calcium voltage-gated channel subunit alpha1 F; congenital stationary night blindness mutant  Name updated 68913 APPROVED
2018-09-07 SD-Cacna1f csnb  calcium voltage-gated channel subunit alpha1 F; congenital stationary night blindness mutant  SD-Cacna1fcsnb  calcium voltage-gated channel subunit alpha1 F;congenital stationary night blindness mutant  Symbol and/or name change 68913 APPROVED