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General

Strain: LE-Mbp^md

Symbol:

LE-Mbp^md

Strain:

LE-Mbp^md

RGD ID:

1358923

Citation ID:

RRID:RGD_1358923

Ontology ID:

RS:0000426

Alleles:

Mbp^md; Mbp

Also Known As:

LE-Mbpmd; LES;Long Evans Shaker; LE-Mbp^[md]

Type:

mutant

Available Source:

Not Available

Origination:

Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Canada

Description:

A spontaneous tremor rat was originated from in-house breeding colony , after purchased from Charles River Laboratory 12 years earlier, at McMaster University Central Animal Facility, Hamilton, Ontario, Canada. 10-12 days old rats had tremors that were followed by ataxia, hind limb paresis, episodes of immobility, and seizures by 5-14 weeks.

Last Known Status:

Unknown

Position

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	18	75,855,878 - 75,966,404	RGD_MAPPER_PIPELINE	mRatBN7.2
Rnor_6.0	18	79,326,738 - 79,437,310	RGD_MAPPER_PIPELINE	Rnor6.0
Rnor_5.0	18	78,385,304 - 78,504,226	RGD_MAPPER_PIPELINE	Rnor5.0
RGSC_v3.4	18	78,943,608 - 79,057,329	RGD_MAPPER_PIPELINE	RGSC3.4

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

demyelinating disease (IAGP)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

ataxia (IAGP)

dysmyelination (IAGP)

tremors (IAGP)

References

References - curated

#	Reference Title	Reference Citation
1.	Familial dysmyelination in a Long Evans rat mutant.	Delaney KH, etal., Lab Anim Sci 1995 Oct;45(5):547-53.
2.	Structural and functional alterations of spinal cord axons in adult Long Evans Shaker (LES) dysmyelinated rats.	Eftekharpour E, etal., Exp Neurol 2005 Jun;193(2):334-49.
3.	Insertion of a retrotransposon in Mbp disrupts mRNA splicing and myelination in a new mutant rat.	O'Connor LT, etal., J Neurosci 1999 May 1;19(9):3404-13.
4.	RGD Strain RSO annotation pipeline	RGD Automated Pipelines

Region

Additional Information

RGD Curation Notes

Note Type	Note	Reference
strain_characteristics	Lack myelin formation at all levels in the central nervous system.	1358775
strain_other	These have disrupted Mbp gene due to the insertion of an endogenous retrotransposon into the noncoding region of the intron 3.	1358763
strain_other	Dispersed labeling of Kv1.1 and Kv1.2, K⁺ channels and of Caspr, a protein confined to paranodes, velocity and high frequency conduction failure.	1358762

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2017-04-05	LE-Mbp^md		LE-Mbp^md		Symbol updated	68687	APPROVED
2017-04-05	LE-Mbp^md		LE-Mbp^md		Symbol updated	68687	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Strain: LE-Mbpmd

Mammalian Phenotype

Strain: LE-Mbp^md