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Strain: LE-Mbpmd

Symbol: LE-Mbpmd
Strain: LE-Mbpmd
RGD ID: 1358923
Citation ID: RRID:RGD_1358923
Ontology ID: RS:0000426
Alleles: Mbpmd;   Mbp
Previously known as: LE-Mbpmd; LES;Long Evans Shaker
Type: mutant
Source: Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Canada
Origin: A spontaneous tremor rat was originated from in-house breeding colony , after purchased from Charles River Laboratory 12 years earlier, at McMaster University Central Animal Facility, Hamilton, Ontario, Canada. 10-12 days old rats had tremors that were followed by ataxia, hind limb paresis, episodes of immobility, and seizures by 5-14 weeks.
Last Known Status: Unknown
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21875,855,878 - 75,966,404RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.01879,326,738 - 79,437,310RGD_MAPPER_PIPELINERnor6.0
Rnor_5.01878,385,304 - 78,504,226RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.41878,943,608 - 79,057,329RGD_MAPPER_PIPELINERGSC3.4

Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
ataxia  (IAGP)
dysmyelination  (IAGP)
tremors  (IAGP)


References - curated
# Reference Title Reference Citation
1. Familial dysmyelination in a Long Evans rat mutant. Delaney KH, etal., Lab Anim Sci 1995 Oct;45(5):547-53.
2. Structural and functional alterations of spinal cord axons in adult Long Evans Shaker (LES) dysmyelinated rats. Eftekharpour E, etal., Exp Neurol 2005 Jun;193(2):334-49.
3. Insertion of a retrotransposon in Mbp disrupts mRNA splicing and myelination in a new mutant rat. O'Connor LT, etal., J Neurosci 1999 May 1;19(9):3404-13.
4. RGD Strain RSO annotation pipeline RGD Automated Pipelines


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_characteristics Lack myelin formation at all levels in the central nervous system. 1358775
strain_other These have disrupted Mbp gene due to the insertion of an endogenous retrotransposon into the noncoding region of the intron 3. 1358763
strain_other Dispersed labeling of Kv1.1 and Kv1.2, K+ channels and of Caspr, a protein confined to paranodes, velocity and high frequency conduction failure. 1358762

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-04-05 LE-Mbpmd    LE-Mbpmd    Symbol updated 68687 APPROVED
2017-04-05 LE-Mbpmd    LE-Mbpmd    Symbol updated 68687 APPROVED