Strain Report - Rat Genome Database
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Strain: COP/CrCrl

Symbol: COP/CrCrl
Strain: COP
Substrain: CrCrl
RGD ID: 1358153
RRID: RGD_1358153
Ontology ID: RS:0000185
Also known as: MDC-03-19; COP/CrCrlBR
Type: inbred
Source: Charles River Laboratories
Origin: Inbred strain is from Curtis in 1921 at Columbia University Institute for Cancer Research. To National Cancer Institute Animal Production Program (Cr). To Charles River from the National Cancer Institute in 1998.
Genetic Markers: Hooded
Coat Color: White
Last Known Status: Unknown





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References


Region

Strain QTL Data
Symbol Name Trait
Emca1 Estrogen-induced mammary cancer QTL 1 mammary gland integrity trait   (VT:0010552)    
Emca2 Estrogen-induced mammary cancer QTL 2 mammary gland integrity trait   (VT:0010552)    
Ept1 Estrogen-induced pituitary tumorigenesis QTL 1 pituitary gland mass   (VT:0010496)    
Ept10 Estrogen-induced pituitary tumorigenesis QTL 10 pituitary gland mass   (VT:0010496)    
Ept13 Estrogen-induced pituitary tumorigenesis QTL 13 pituitary gland mass   (VT:0010496)    
Ept2 Estrogen-induced pituitary tumorigenesis QTL 2 pituitary gland mass   (VT:0010496)    
Ept6 Estrogen-induced pituitary tumorigenesis QTL 6 pituitary gland mass   (VT:0010496)    
Ept9 Estrogen-induced pituitary tumorigenesis QTL 9 pituitary gland mass   (VT:0010496)    
Damaging Variants
Number of Damaging Variants
SampleRnor_6.0Rnor_5.0RGSC_v3.4
COP/CrCrl (MCW & UW) 1058
COP/CrCrl (MCW & UW) 1440
COP/CrCrl (MCW & UW) 2462


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_drgs_chems Synthetic estrogen diethylstilbestrol (DES) induces pituitary growth in ACI and COP rats and their F1, F2 and backcross progeny. 1358974
strain_drgs_chems DES induces an increase in the circulating PRL in ACI males as compared to COP males. 1358974
strain_drgs_chems DES treatment on males for 12 weeks induced the development of PRL-producing pituitary tumors comprising of enlarged pituitary glands displaying lactotroph hyperplasia and associated hyperprolactinemia. 1358975
strain_drgs_chems Strain has decreased sensitivity to DES-induced pituitary growth. 1334449
strain_drgs_chems These females are relatively resistant to 17beta-estradiol induced mammary tumorigenesis. 1358956
strain_life_disease F1, F2 and backcross progeny of these rats with ACI show significantly prolonged latency for E2 induced mammary cancer. 1358956
strain_life_disease 17beta-estradiol stimulates mammary cell proliferation and lobuloalveolar hyperplasia. 1358963
strain_life_disease E2 induced atypical epithelial hyperplasia is not present in COP rats which is observed in ACI rats. 1358963
strain_other 12 weeks of E2 treatment in females exhibit an increase in pituitary weight and circulating PRL. 1358963