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Strain: SHR/NCrl

Symbol: SHR/NCrl
Strain: SHR
Substrain: NCrl
RGD ID: 1357994
RRID: RGD_1357994
Ontology ID: RS:0000730
Also known as: MDC-03-01; SHR/NCrlBR; SHR (CRiv)
Type: inbred
Source: Charles River Laboratories
Origin: To Charles River from NIH in 1973 at F32. To N 1966 at F13 from Okamoto. Okamoto, Kyoto School of Medicine, 1963, from outbred Wistar Kyoto male with marked elevation of blood pressure mated to female with slightly elevated blood pressure; brother-sister mating with continued selection for spontaneous hypertension.
Coat Color: Albino
Inbred Generations: F49+
Last Known Status: Live Animals (as of 2020-01-23)






Phenotype Values via PhenoMiner     Click to see Annotation Detail View
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Clinical Measurement
heart rate
left ventricular diastolic blood pressure
left ventricular systolic blood pressure
mean arterial blood pressure
body weight
body temperature
left ventricular developed pressure
red blood cell count
blood hemoglobin level
blood neutrophil count
blood lymphocyte count
blood monocyte count
blood eosinophil count
hematocrit
mean corpuscular volume
plasma anion gap
heart wet weight
heart weight to body weight ratio
lung dry weight to body weight ratio
heart right ventricle weight to left ventricle weight ratio
plasma renin activity level
minute ventilation (VE)
arterial blood flow rate
tidal volume
partial pressure of blood carbon dioxide (Pco2)
percent change in ventilation
respiration rate
mean corpuscular hemoglobin level
mean corpuscular hemoglobin concentration
absolute change in partial pressure of blood carbon dioxide
absolute change in partial pressure of blood oxygen
absolute change in blood pH
serum total cholesterol level
total white blood cell count
total serum bilirubin level
blood pH
partial pressure of blood oxygen
serum bicarbonate level
serum chloride level
serum potassium level
serum sodium level
serum calcium level
percent change in respiration rate
percent change in tidal volume
absolute change in mean arterial blood pressure
absolute change in heart rate
plasma creatinine level
serum phosphate level
serum glucose level
serum albumin level
serum alanine aminotransferase activity level
serum alkaline phosphatase activity level
serum aspartate aminotransferase activity level
plasma total cholesterol level
serum urea nitrogen level
absolute change in plasma renin activity level
serum total protein level
time to onset of heart contraction
time to peak heart contraction
heart contraction pressure
heart left ventricle infarction weight to total heart left ventricle weight ratio
absolute change in body temperature
calculated pulmonary vascular resistance normalized to body weight
FAPGG metabolism-surface area product
methylene blue metabolism-surface area product without auto-oxidation
methylene blue metabolism-surface area product after auto-oxidation
methylene blue to FAPGG metabolism-surface area product ratio
dose of methacholine at which pulmonary conductance is half its pretreatment value
fractional change in blood vessel diameter per unit change in intravascular pressure
concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50)
logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50)
concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50)
logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)
concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50)
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)
maximum contractile force per wet weight of aorta
acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel
sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel
hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel
percent change in heart rate
percent change in arterial blood flow rate
percent change in left ventricular developed pressure
percent change in left ventricular systolic blood pressure
urine total protein excretion rate
urine albumin excretion rate
urine sodium excretion rate
creatinine clearance
heart effluent lactate dehydrogenase activity level normalized to heart weight
liver cholesterol level
brain cholesterol level
brain phytosterol level
brain campesterol level
brain sitosterol level
liver sitosterol level
liver campesterol level
liver phytosterol level
plasma sitosterol level
plasma campesterol level
plasma phytosterol level
serum globulin level

References


Region


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_characteristics the La Jolla colony of SHR rats exhibit a G -> C point mutation at position 1684 of the angiotensinogen gene which appears to affect the secondary structure of the mRNA and strengthen its interaction with a 12 kDa mRNA-stabilizing protein in response to stimulation by angioensin II 1358960
strain_life_disease The blood pressure of females is 145 mmHg and of males is 154 mmHg. 629526
strain_other The average weight of females is 164g and of males 279g. 629526

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-08-12 SHR/NCrl    SHR/NCrl    Name updated 68913 APPROVED
2013-08-12 SHR/NCrl    SHR/NCrl    Name updated 68913 APPROVED