Strain Report - Rat Genome Database

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Strain: SS.WKY-(D2N35-Mme),MNS-(D10Mit11-D10M11Mit119)/Mco

Symbol: SS.WKY-(D2N35-Mme),MNS-(D10Mit11-D10M11Mit119)/Mco
Strain: SS.WKY-(D2N35-Mme),MNS-(D10Mit11-D10M11Mit119)
Substrain: Mco
RGD ID: 1357179
Citation ID: RRID:RGD_1357179
Ontology ID: RS:0000920
Also Known As: Chr 2/10 double congenic; SSJr.WKY-(D2N35-Mme);MNS-(D10Mit11-D10M11Mit119)/Mco; SS.WKY-(D2N35-Mme),MNS-(D10Mit11-D10M11Mit119)/Mco
Type: congenic
Available Source: Not Available
Origination: Medical College of Ohio, Toledo, Ohio, USA
Description: SS.WKY-(D2N35-Mme)/Mco and SS.MNS-(D10Mit11-D10M11Mit119)/Mco were crossed and the F1 were backcrossed to SS.WKY-(D2N35-Mme)/Mco. Rats that were homozygous on the chr 2 loci were selected and crossed with the ones that were homozygous on the chr 10 loci. This produced the double congenic strain which was maintained by brother-sister mating
Last Known Status: Unknown

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Mammalian Phenotype

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Clinical Measurement
systolic blood pressure


References - curated
# Reference Title Reference Citation
1. Construction of a double congenic strain to prove an epistatic interaction on blood pressure between rat chromosomes 2 and 10. Rapp JP, etal., J Clin Invest 1998 Apr 15;101(8):1591-5.
2. RGD Strain RSO annotation pipeline RGD Automated Pipelines


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_characteristics This double congenic strain was taken as the baseline and all the blood pressure measurements were compared to this control. 619640