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Strain Registration

Strain: GK/Jcl

Symbol: GK/Jcl
Strain: GK
Substrain: Jcl
RGD ID: 13506739
Citation ID: RRID:RGD_13506739
Ontology ID: RS:0004580
Previously known as: JCL:rDB-0001
Type: inbred
Source: CLEA Japan, Inc
Origin: The Goto-Kakizaki (GK) rat is a non-obese Wistar substrain which develops Type 2 diabetes mellitus early in life. The model was developed by Goto and Kakizaki at Tohoku University, Sendai, Japan in 1975. The GK line was established by repeated inbreeding from Wistar rats selected at the upper limit of normal distribution for glucose tolerance. Repeated selection of rats with tendency to lowest glucose tolerance resulted in clear-cut glucose intolerance after five generations.This strain was introduced from Tohoku University, and CLEA Japan Inc started its production and supply as GK/Jcl.
Last Known Status: Unknown





References

References - curated
# Reference Title Reference Citation
1. Hypoglycemic and hypolipidemic effects of hesperidin and cyclodextrin-clathrated hesperetin in Goto-Kakizaki rats with type 2 diabetes. Akiyama S, etal., Biosci Biotechnol Biochem. 2009 Dec;73(12):2779-82. doi: 10.1271/bbb.90576. Epub 2009 Dec 7.
2. Development of diabetes in the non-obese NIDDM rat (GK rat). Goto Y, etal., Adv Exp Med Biol. 1988;246:29-31. doi: 10.1007/978-1-4684-5616-5_4.
3. The GK rat: a prototype for the study of non-overweight type 2 diabetes. Portha B, etal., Methods Mol Biol. 2012;933:125-59. doi: 10.1007/978-1-62703-068-7_9.
4. Modulation of cardiac connexin-43 by omega-3 fatty acid ethyl-ester supplementation demonstrated in spontaneously diabetic rats. Radosinska J, etal., Physiol Res. 2015;64(6):795-806. Epub 2015 Oct 8.

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