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Strain Registration

Strain: GK/Par

Symbol: GK/Par
Strain: GK
Substrain: Par
RGD ID: 13506738
Citation ID: RRID:RGD_13506738
Ontology ID: RS:0004579
Type: inbred
Available Source: Not Available
Description: The Goto-Kakizaki (GK) rat is a non-obese Wistar substrain which develops Type 2 diabetes mellitus early in life. The model was developed by Goto and Kakizaki at Tohoku University, Sendai, Japan in 1975. The GK line was established by repeated inbreeding from Wistar rats selected at the upper limit of normal distribution for glucose tolerance. Repeated selection of rats with tendency to lowest glucose tolerance resulted in clear-cut glucose intolerance after five generation.In 1988, GK/Par substrain was established in Paris, France by initiating breeding pairs F35 from Japanese colonies .
Last Known Status: Unknown





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References

References - curated
# Reference Title Reference Citation
1. Protective Effect of Resveratrol against Ischemia-Reperfusion Injury via Enhanced High Energy Compounds and eNOS-SIRT1 Expression in Type 2 Diabetic Female Rat Heart. Fourny N, etal., Nutrients. 2019 Jan 6;11(1). pii: nu11010105. doi: 10.3390/nu11010105.
2. Beta-cell insensitivity to glucose in the GK rat, a spontaneous nonobese model for type II diabetes. Portha B, etal., Diabetes. 1991 Apr;40(4):486-91.
3. The GK rat: a prototype for the study of non-overweight type 2 diabetes. Portha B, etal., Methods Mol Biol. 2012;933:125-59. doi: 10.1007/978-1-62703-068-7_9.

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