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Strain: F344-Il2rgem1Iexas

Symbol: F344-Il2rgem1Iexas
Strain: F344-Il2rgem1
Substrain: Kyo
RGD ID: 13464263
Citation ID: RRID:RGD_13464263
Ontology ID: RS:0004566
Alleles: Il2rgem1Iexas
Previously known as: NBRP Rat No: 0883; X-SCID, F344-Il2rgem1Iexas; F344-Il2rgem1Iexas
Type: mutant
Source: National BioResource Project for the Rat in Japan
Origin: This strain was established by CRISPR/Cas9 targeting rat Il2rg gene using electroporation. background strain: F344/Jcl. This strain shows severe combined immunodeficiency (SCID) caused by 5-bp deletion of Il2rg gene. This strain grows normally under SPF condition.
Coat Color: albino
Inbred Generations: N3
Last Known Status: Live Animals; Cryopreserved Sperm (as of 2018-01-02)
Research Usage Immunology
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X66,395,330 - 66,399,026RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.0X71,165,378 - 71,169,078RGD_MAPPER_PIPELINERnor6.0
Rnor_5.0X72,017,856 - 72,021,516RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.4X89,342,055 - 89,345,715RGD_MAPPER_PIPELINERGSC3.4


References - curated
# Reference Title Reference Citation
1. Generation of knockout rats with X-linked severe combined immunodeficiency (X-SCID) using zinc-finger nucleases. Mashimo T, etal., PLoS One. 2010 Jan 25;5(1):e8870.
2. A high-quality severe combined immunodeficiency (SCID) rat bioresource. Miyasaka Y, etal., PLoS One. 2022 Aug 12;17(8):e0272950. doi: 10.1371/journal.pone.0272950. eCollection 2022.
3. Strains registered by the National Bio Resource Project for the Rat in Japan Personal Communication with NBRP


Additional Information