Strain: BN-Crb1m1

Symbol: BN-Crb1m1
Strain: BN-Crb1m1
Ontology ID: RS:0004562
Alleles: Crb1m1
Also known as: BN-Crb1m1
Type: mutant
Source: Not Available
Origin: This Brown Norway from Janvier rat strain spontaneously develops progressive focal retinal layer disorganization, loss of photoreceptors, cystic cavitation, and RMG abnormalities associated with early retinal vascular telangiectasia and late stage subretinal neovascularization. This phenotype bears reminiscent of human Macular telangiectasia 2. A deletion insertion mutation in exon 6 of the rat crb1 was identified to be responsible for this retinal phenotype.
Genetic Status: Homozygous
Last Known Status: Unknown
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01356,270,519 - 56,462,893RGD_MAPPER_PIPELINERnor6.0
Rnor_5.01361,292,273 - 61,480,872RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.41352,558,317 - 52,725,099RGD_MAPPER_PIPELINERGSC3.4

Disease Annotations
Phenotype Annotations
Experimental Data Annotations
References - curated
RGD Disease Portals


Additional Information

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Strain Registration

RGD Object Information
RGD ID: 13451132
Created: 2017-11-15
Species: Rattus norvegicus
Last Modified: 2017-11-15
Status: ACTIVE