Strain Report - Rat Genome Database

Name: LEC/Tj
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Strain Registration

General

Strain: LEC/Tj

Symbol:

LEC/Tj

Strain:

LEC

Substrain:

RGD ID:

1302721

Citation ID:

RRID:RGD_1302721

Ontology ID:

RS:0000448

Alleles:

Atp7b^hts

Previously known as:

NBRP Rat No: 0051

Type:

mutant

Source:

National BioResource Project for the Rat in Japan

Origin:

Found in Long Evans strain at Kobe University > Inbreeding at Hokkaido University > Otsuka Pharmaceutical Co. > The University of Tokushima 1989

Inbred Generations:

F45

Last Known Status:

Cryopreserved Embryo

Research Usage

Cancer

Position

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	16	69,952,286 - 70,024,404	RGD_MAPPER_PIPELINE	mRatBN7.2
Rnor_6.0	16	74,865,516 - 74,944,935	RGD_MAPPER_PIPELINE	Rnor6.0
Rnor_5.0	16	74,495,179 - 74,575,822	RGD_MAPPER_PIPELINE	Rnor5.0
RGSC_v3.4	16	74,607,988 - 74,680,080	RGD_MAPPER_PIPELINE	RGSC3.4

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

liver carcinoma (IAGP)

Liver Neoplasms (IAGP)

renal adenoma (IAGP)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

abnormal CD4-positive T cell differentiation (IAGP)

hepatic megalocytosis (IAGP)

jaundice (IAGP)

References

References - curated

#	Reference Title	Reference Citation
1.	Maturational arrest of thymocyte development is caused by a deletion in the receptor-like protein tyrosine phosphatase kappa gene in LEC rats.	Kose H, etal., Genomics. 2007 Jun;89(6):673-7. doi: 10.1016/j.ygeno.2007.03.001. Epub 2007 Apr 16.
2.	Role of Atp7b gene in spontaneous and N-diethylnitrosamine-induced carcinogenesis in a new congenic strain, WKAH.C-Atp7b rats.	Minami T, etal., Jpn J Cancer Res 2001 Aug;92(8):841-7.
3.	Point mutation of aldehyde dehydrogenase-2 gene in mutant strains of Long-Evans rats.	Nakajima M, etal., Alcohol Alcohol 1994;29 Suppl 1:39-43.
4.	Strains registered by the National Bio Resource Project for the Rat in Japan	Personal Communication with NBRP
5.	RGD Strain RSO annotation pipeline	RGD Automated Pipelines
6.	Low susceptibility to N-ethyl-N-nitrosourea-induced transplacental carcinogenesis in Long-Evans Cinnamon (LEC) rats.	Tsuchigauchi T, etal., J Med Invest. 2009 Aug;56(3-4):93-8.

Region

Damaging Variants

	Number of Damaging Variants
Sample	Rnor_6.0	Rnor_5.0	RGSC_v3.4
LEC/Tj (KyushuU)		1434

Additional Information

RGD Curation Notes

Note Type	Note	Reference
strain_drgs_chems	Resistant to ENU-induced transplacental carcinogenesis	2316901
strain_life_disease	Hepatitis, jaundice , a defect of T cell maturation	1302502
strain_reproduction	Good breeding performance	1302502

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2012-05-08	LEC/Tj		LEC/Tj		Name updated	68913	APPROVED
2012-05-08	LEC/Tj		LEC/Tj		Name updated	68913	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Strain: LEC/Tj

Mammalian Phenotype