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Strain Registration

Strain: TRM/Kyo

Symbol: TRM/Kyo
Strain: TRM
Substrain: Kyo
Full Name: tremor rat
RGD ID: 1302702
Citation ID: RRID:RGD_1302702
Ontology ID: RS:0000940
Alleles: Hcn1A354V;   Aspa
Previously known as: NBRP Rat No: 0015; MDC-02-29
Type: segregating_inbred
Source: National BioResource Project for the Rat in Japan
Origin: In 1980, a spontaneous tremor mutant rat was found in the colony of Kyo:Wistar (Yamada, 1985). This disorder was found to be caused by an autosomal recessive gene and was designated tremor (tm). Deletion of Aspa gene was identified in the animal with no aspartoacylase activity in the brain and measurable level of activity in the kidney. TRM was established as a segregating inbred strain. In F18 progeny, a rat which did not have tm mutation was separated and established as a control strain of WTC (NBRP No.0020). (Dec 8, 2010)
Coat Color: Albino
Inbred Generations: F51
Last Known Status: Live Animals; Cryopreserved Embryo; Cryopreserved Sperm (as of 2018-01-03)
Research Usage Neurobiology

Mutant Strains
TRMR/Kyo
WTC/Kyo




Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype

Phenotype Values via PhenoMiner     Click to see Annotation Detail View
Options:  View chart  |  Download data table  |  View expanded data table

Clinical Measurement
heart rate
systolic blood pressure
body weight
body temperature
red blood cell count
blood hemoglobin level
white blood cell count
platelet count
hematocrit
mean corpuscular volume
plasma glucose level
plasma aspartate aminotransferase activity level
plasma alanine aminotransferase activity level
plasma alkaline phosphatase activity level
plasma total protein level
plasma albumin level
plasma phosphate level
plasma chloride level
plasma sodium level
plasma potassium level
heart wet weight
heart weight to body weight ratio
both kidneys wet weight
lung wet weight
urine potassium level
urine sodium level
brain weight to body weight ratio
both kidneys wet weight as percentage of body weight
liver weight as percentage of body weight
spleen weight to body weight ratio
brain wet weight
lung weight to body weight ratio
liver wet weight
both adrenal glands wet weight
spleen wet weight
both testes wet weight
activated partial thromboplastin time
prothrombin time
timed urine volume
mean corpuscular hemoglobin
mean corpuscular hemoglobin concentration
blood basophil count to total leukocyte count ratio
blood eosinophil count to total leukocyte count ratio
blood lymphocyte count to total leukocyte count ratio
blood monocyte count to total leukocyte count ratio
total plasma calcium level
urine chloride level
plasma creatinine level
plasma triglyceride level
plasma total cholesterol level
plasma urea nitrogen level
both adrenal glands weight to body weight ratio
plasma high density lipoprotein cholesterol level
plasma low density lipoprotein cholesterol level
both testes wet weight to body weight ratio
urine sodium excretion rate to body weight ratio
timed urine volume to body weight ratio
urine chloride excretion rate to body weight ratio
urine potassium excretion rate to body weight ratio
plasma total bilirubin level
blood segmented neutrophil count to total leukocyte count ratio
blood band neutrophil count to total leukocyte count ratio
non-specified leukocyte count to total leukocyte count ratio
plasma albumin to plasma total protein ratio

References

References - curated
# Reference Title Reference Citation
1. Infertility associated with meiotic failure in the tremor rat (tm/tm) is caused by the deletion of spermatogenesis associated 22. Ishishita S, etal., Exp Anim. 2013;62(3):219-27. doi: 10.1538/expanim.62.219.
2. Accumulation of N-acetyl-L-aspartate in the brain of the tremor rat, a mutant exhibiting absence-like seizure and spongiform degeneration in the central nervous system. Kitada K, etal., J Neurochem 2000 Jun;74(6):2512-9.
3. Hcn1 is a tremorgenic genetic component in a rat model of essential tremor. Ohno Y, etal., PLoS One. 2015 May 13;10(5):e0123529. doi: 10.1371/journal.pone.0123529. eCollection 2015.
4. Strains registered by the National Bio Resource Project for the Rat in Japan Personal Communication with NBRP
5. RGD Strain RSO annotation pipeline RGD Automated Pipelines
6. SNP and haplotype mapping for genetic analysis in the rat. Saar K, etal., Nat Genet. 2008 May;40(5):560-6.
7. A new model of petit mal epilepsy: spontaneous spike and wave discharges in tremor rats. Serikawa T, etal., Lab Anim. 1987 Jan;21(1):68-71. doi: 10.1258/002367787780740635.
8. Rats with congenital tremor and curled whiskers and hair. Yamada J, etal., Jikken Dobutsu. 1985 Apr;34(2):183-8.

Region


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_other The tremor rat has a large deletion (200kb) spanning the aspartoacylase (ASPA) coding region. The deleted resion includes several other genes such as Trpv3, which is known to be related with abnormal hair. 628404

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-05-04 TRM/Kyo  tremor rat  TRM/Kyo  tremor rat  Name updated 68913 APPROVED