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Strain: SER/Kyo

Symbol: SER/Kyo
Strain: SER
Substrain: Kyo
Full Name: spontaneously epileptic rat
RGD ID: 1302695
RRID: RGD_1302695
Ontology ID: RS:0000711
Alleles: Aspa;   Atrn
Also known as: NBRP Rat No: 0012; MDC-02-21
Type: segregating_inbred
Source: National BioResource Project for the Rat in Japan
Origin: Spontaneously Epileptic Rat was developed as a double mutant by Serikawa by crossing zi rats (derived from SD), carrying an autosomal recessive attractin mutation with trm rats (derived from Kyo:Wistar), carrying a genomic deletion comprising Aspartate Ac
Coat Color: Albino
Inbred Generations: F59
Last Known Status: Live Animals; Cryopreserved Embryo; Cryopreserved Sperm
Research Usage Neurobiology





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Clinical Measurement
heart rate
systolic blood pressure
body weight
body temperature
red blood cell count
blood hemoglobin level
white blood cell count
platelet count
hematocrit
mean corpuscular volume
plasma glucose level
plasma aspartate aminotransferase activity level
plasma alanine aminotransferase activity level
plasma alkaline phosphatase activity level
plasma total protein level
plasma albumin level
plasma phosphate level
plasma chloride level
plasma sodium level
plasma potassium level
heart wet weight
heart weight to body weight ratio
both kidneys wet weight
lung wet weight
urine potassium level
urine sodium level
brain weight to body weight ratio
both kidneys wet weight as percentage of body weight
liver weight as percentage of body weight
spleen weight to body weight ratio
brain wet weight
lung weight to body weight ratio
liver wet weight
both adrenal glands wet weight
spleen wet weight
both testes wet weight
activated partial thromboplastin time
prothrombin time
timed urine volume
mean corpuscular hemoglobin level
mean corpuscular hemoglobin concentration
blood basophil count to total leukocyte count ratio
blood eosinophil count to total leukocyte count ratio
blood lymphocyte count to total leukocyte count ratio
blood monocyte count to total leukocyte count ratio
total plasma calcium level
urine chloride level
plasma creatinine level
plasma triglyceride level
plasma total cholesterol level
plasma urea nitrogen level
both adrenal glands weight to body weight ratio
plasma high density lipoprotein cholesterol level
plasma low density lipoprotein cholesterol level
both testes wet weight to body weight ratio
urine sodium excretion rate to body weight ratio
timed urine volume to body weight ratio
urine chloride excretion rate to body weight ratio
urine potassium excretion rate to body weight ratio
total plasma bilirubin level
blood segmented neutrophil count to total leukocyte count ratio
blood band neutrophil count to total leukocyte count ratio
non-specified leukocyte count to total leukocyte count ratio
plasma albumin to plasma total protein ratio

References


Region


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_characteristics In the rat, zitter (zi) and tremor (tm) are autosomal recessive mutations that in homozygotes caused curled whisker hair, and tremor when the animals move. In both mutant types, the presence of many vacuoles gives the central nervous system a spongy appearance. In animals homozygous for both mutations, an epileptic seizure frequently and spontaneously occurred from 7 or 8 weeks of age. 1302445
strain_life_disease Epileptic seizures were due to the enhancement of calcium ion influx in the hippocampal CA3 neurons induced by enhanced voltage-dependent calcium channels 1600256
strain_other 8 bp deletion of Atrn gene for zi allele, genomic deletion of Aspa gene for tm allele. 1302445
strain_reproduction Maintained in homozygous zi allele and heterozygous tm allele. 1302445

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-05-04 SER/Kyo  spontaneously epileptic rat  SER/Kyo  spontaneously epileptic rat  Name updated 68913 APPROVED