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Strain Registration

Strain: DMY/Kyo

Symbol: DMY/Kyo
Strain: DMY
Substrain: Kyo
Full Name: demyelination rat
RGD ID: 1302645
Citation ID: RRID:RGD_1302645
Ontology ID: RS:0000252
Alleles: Mrs2dmyKyo
Previously known as: NBRP Rat No: 0003; MDC-01-69
Type: mutant
Source: National BioResource Project for the Rat in Japan
Origin: From a closed but not inbred colony of Sprague Dawley (SD) rats in the laboratory animal facilities of the Universitat Autonoma de Barcelona (Bellaterra Campus) in 1991. Via Institute Pasteur, Paris, to Kyoto University (1996).
Coat Color: Albino
Last Known Status: Live Animals; Cryopreserved Embryo; Cryopreserved Sperm
Research Usage Neurobiology
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21740,063,924 - 40,087,073RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.01742,064,271 - 42,083,602RGD_MAPPER_PIPELINERnor6.0
Rnor_5.01743,932,146 - 43,951,399RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.41747,124,915 - 47,142,840RGD_MAPPER_PIPELINERGSC3.4





Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype

Phenotype Values via PhenoMiner     Click to see Annotation Detail View
Options:  View chart  |  Download data table  |  View expanded data table

Clinical Measurement
heart rate
systolic blood pressure
body weight
body temperature
red blood cell count
blood hemoglobin level
white blood cell count
platelet count
hematocrit
mean corpuscular volume
plasma glucose level
plasma aspartate aminotransferase activity level
plasma alanine aminotransferase activity level
plasma alkaline phosphatase activity level
plasma total protein level
plasma albumin level
plasma phosphate level
plasma chloride level
plasma sodium level
plasma potassium level
heart wet weight
heart weight to body weight ratio
both kidneys wet weight
lung wet weight
urine potassium level
urine sodium level
brain weight to body weight ratio
both kidneys wet weight as percentage of body weight
liver weight as percentage of body weight
spleen weight to body weight ratio
brain wet weight
lung weight to body weight ratio
liver wet weight
both adrenal glands wet weight
spleen wet weight
both testes wet weight
activated partial thromboplastin time
prothrombin time
timed urine volume
mean corpuscular hemoglobin
mean corpuscular hemoglobin concentration
blood basophil count to total leukocyte count ratio
blood eosinophil count to total leukocyte count ratio
blood lymphocyte count to total leukocyte count ratio
blood monocyte count to total leukocyte count ratio
total plasma calcium level
urine chloride level
plasma creatinine level
plasma triglyceride level
plasma total cholesterol level
plasma urea nitrogen level
both adrenal glands weight to body weight ratio
plasma high density lipoprotein cholesterol level
plasma low density lipoprotein cholesterol level
both testes wet weight to body weight ratio
urine sodium excretion rate to body weight ratio
timed urine volume to body weight ratio
urine chloride excretion rate to body weight ratio
urine potassium excretion rate to body weight ratio
plasma total bilirubin level
blood segmented neutrophil count to total leukocyte count ratio
blood band neutrophil count to total leukocyte count ratio
non-specified leukocyte count to total leukocyte count ratio
plasma albumin to plasma total protein ratio

References

References - curated
# Reference Title Reference Citation
1. A rat mutation producing demyelination (dmy) maps to chromosome 17. Kuramoto T, etal., Mamm Genome 1996 Dec;7(12):890-4.
2. A mutation in the gene encoding mitochondrial Mg²+ channel MRS2 results in demyelination in the rat. Kuramoto T, etal., PLoS Genet. 2011 Jan 6;7(1):e1001262. doi: 10.1371/journal.pgen.1001262.
3. Strains registered by the National Bio Resource Project for the Rat in Japan Personal Communication with NBRP
4. RGD Strain RSO annotation pipeline RGD Automated Pipelines
5. SNP and haplotype mapping for genetic analysis in the rat. Saar K, etal., Nat Genet. 2008 May;40(5):560-6.

Region


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_characteristics An autosomal recessive mutation exhibiting severe myelin breakdown, mainly at the level of the lumbar segments of the spinal cord and without any associated inflammation recessive maps to rat Chromosome 17. The pathology of the demyelination process and the chromosomal localization indicate that this mutation has no known equivalent in either mouse or human 1300413