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Strain: WKY.SHRSP-(D1Wox29-D1Arb21)/Izm

Symbol: WKY.SHRSP-(D1Wox29-D1Arb21)/Izm
Strain: WKY.SHRSP-(D1Wox29-D1Arb21)
Substrain: Izm
RGD ID: 1302636
Citation ID: RRID:RGD_1302636
Ontology ID: RS:0001054
Also known as: Wpch1.0; WKYpch1.0; NBRP Rat No: 0174; WKY.SHRSP-(D1Wox29-D1Arb21)/Izm
Type: congenic
Source: National BioResource Project for the Rat in Japan
Origin: This congenic strain contains an SHRSP/Izm chromsome 1 segment containing a blood pressure QTL transferred to a WKY/Izm background
Last Known Status: Cryopreserved Embryo
Research Usage Cardio Hypertension
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21123,350,408 - 182,418,476RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.01130,779,148 - 199,254,774RGD_MAPPER_PIPELINERnor6.0
Rnor_5.01131,822,204 - 206,277,202RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.41124,614,679 - 187,092,492RGD_MAPPER_PIPELINERGSC3.4

Disease Annotations     Click to see Annotation Detail View



Position Markers

Flank 1 / 1 (D1Wox29)
Rat AssemblyChrPosition (strand)Source
mRatBN7.21123,350,408 - 123,350,581 (+)MAPPER
Rnor_6.01130,779,148 - 130,779,320NCBI
Rnor_5.01131,822,204 - 131,822,376UniSTS
RGSC_v3.41124,614,680 - 124,614,852UniSTS
RGSC_v3.41124,614,679 - 124,614,852RGD
RGSC_v3.11124,693,023 - 124,693,195RGD
Celera1115,524,239 - 115,524,411UniSTS
RH 3.4 Map11458.6UniSTS
RH 3.4 Map11458.6RGD

Flank 2 / 1 (D1Arb21)
Rat AssemblyChrPosition (strand)Source
mRatBN7.21182,418,219 - 182,418,476 (+)MAPPER
Rnor_6.01199,254,518 - 199,254,774NCBI
Rnor_5.01206,276,946 - 206,277,202UniSTS
RGSC_v3.41187,092,236 - 187,092,492UniSTS
RGSC_v3.41187,092,235 - 187,092,492RGD
RGSC_v3.11187,242,116 - 187,242,373RGD
Celera1180,069,264 - 180,069,520UniSTS
FHH x ACI Map185.51RGD
FHH x ACI Map185.51UniSTS
Cytogenetic Map1q36UniSTS
Strain QTL Data
Symbol Name Trait
Cstrr1 Cold stress response QTL 1 catecholamine amount   (VT:0010543)    
Stresp23 Stress response QTL 23 kidney sympathetic nerve activity   (VT:0004050)    

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_phys_biochem displays increased urinary excretion of norepinephrine (NE) and vanillylmandelic acid, increased plasma NE levels, and increased blood pressure in response to cold stress at levels greater than those observed in the parental WKY strain under cold stress 1302892
strain_phys_biochem After air-jet stress shows a significant increase in renal sympathetic nerve activity and mean arterial pressure compared with WKY strain. 1578503
strain_phys_biochem Basal membrane potential of rostral ventrolateral medulla (RVLM) neurons was less than that of WKY/Izm 2302408
strain_phys_biochem Depolarization of RVLM neurons in response to angiotensin II was larger than that of WKY/Izm 2302408
strain_phys_biochem significant increase in urinary norepinephrine, vanillylmandelic acid, and blood pressure compared to WKY animals was observed 1302892

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-05-10 WKY.SHRSP-(D1Wox29-D1Arb21)/Izm    WKY.SHRSP-(D1Wox29-D1Arb21)/Izm    Name updated 68913 APPROVED
2012-05-10 WKY.SHRSP-(D1Wox29-D1Arb21)/Izm    WKY.SHRSP-(D1Wox29-D1Arb21)/Izm    Name updated 68913 APPROVED