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Strain: WKY.SHRSP-(D1Wox29-D1Arb21)/Izm

Symbol: WKY.SHRSP-(D1Wox29-D1Arb21)/Izm
Strain: WKY.SHRSP-(D1Wox29-D1Arb21)
Substrain: Izm
RGD ID: 1302636
Citation ID: RRID:RGD_1302636
Ontology ID: RS:0001054
Previously known as: WKYpch1.0; NBRP Rat No: 0174; WKY.SHRSP-(D1Wox29-D1Arb21)/Izm; Wpch1.0
Type: congenic
Source: National BioResource Project for the Rat in Japan
Origin: This congenic strain contains an SHRSP/Izm chromsome 1 segment containing a blood pressure QTL transferred to a WKY/Izm background
Last Known Status: Cryopreserved Embryo
Research Usage Cardio Hypertension
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21123,350,408 - 182,418,476RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.01130,779,148 - 199,254,774RGD_MAPPER_PIPELINERnor6.0
Rnor_5.01131,822,204 - 206,277,202RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.41124,614,679 - 187,092,492RGD_MAPPER_PIPELINERGSC3.4





Disease Annotations     Click to see Annotation Detail View


References

References - curated
# Reference Title Reference Citation
1. Exaggerated response to restraint stress in rats congenic for the chromosome 1 blood pressure quantitative trait locus. Cui ZH, etal., Clin Exp Pharmacol Physiol 2003 Jul;30(7):464-9.
2. Exaggerated response to cold stress in a congenic strain for the quantitative trait locus for blood pressure. Cui ZH, etal., J Hypertens 2004 Nov;22(11):2103-9.
3. Relation of Blood Pressure Quantitative Trait Locus on Rat Chromosome 1 to Hyperactivity of Rostralventrolateral Medulla. Iigaya K, etal., Hypertension. 2008 Dec 1.
4. Strains registered by the National Bio Resource Project for the Rat in Japan Personal Communication with NBRP
5. RGD Strain RSO annotation pipeline RGD Automated Pipelines
6. Enhanced sympathetic control of renal function in rats congenic for the hypertension-related region on chromosome 1. Wang T, etal., Clin Exp Pharmacol Physiol. 2005 Dec;32(12):1055-60.
7. SYMPATHETIC REGULATION OF RENAL FUNCTION IN STROKE-PRONE SPONTANEOUSLY HYPERTENSIVE RATS CONGENIC FOR CHROMOSOME 1 BLOOD PRESSURE QUANTITATIVE TRAIT LOCI. Wang T, etal., Clin Exp Pharmacol Physiol. 2008 Jun 18;.
8. Sympathetic regulation of the renal functions in rats reciprocally congenic for chromosome 1 blood pressure quantitative trait locus. Wang T, etal., Hypertens Res. 2008 Mar;31(3):561-8.
9. A 1.8-Mbp fragment on chromosome 1 affects sympathetic response to stress: evaluation in reciprocal congenic strains between stroke-prone spontaneously hypertensive rat and Wistar-Kyoto rat. Xiao B, etal., J Hypertens. 2010 Nov 8.
10. Sympathetic hyperreactivity to air-jet stress in the chromosome 1 blood pressure quantitative trait locus congenic rats. Yamazato M, etal., Am J Physiol Regul Integr Comp Physiol. 2006 Mar;290(3):R709-14. Epub 2005 Oct 20.
11. Congenic removal of a QTL for blood pressure attenuates infarct size produced by middle cerebral artery occlusion in hypertensive rats. Yao H, etal., Physiol Genomics. 2007 Feb 27;.

Region

Position Markers

Flank 1 / 1 (D1Wox29)
Rat AssemblyChrPosition (strand)Source
mRatBN7.21123,350,408 - 123,350,581 (+)MAPPER
Rnor_6.01130,779,148 - 130,779,320NCBI
Rnor_5.01131,822,204 - 131,822,376UniSTS
RGSC_v3.41124,614,679 - 124,614,852RGD
RGSC_v3.41124,614,680 - 124,614,852UniSTS
RGSC_v3.11124,693,023 - 124,693,195RGD
Celera1115,524,239 - 115,524,411UniSTS
RH 3.4 Map11458.6RGD
RH 3.4 Map11458.6UniSTS

Flank 2 / 1 (D1Arb21)
Rat AssemblyChrPosition (strand)Source
mRatBN7.21182,418,219 - 182,418,476 (+)MAPPER
Rnor_6.01199,254,518 - 199,254,774NCBI
Rnor_5.01206,276,946 - 206,277,202UniSTS
RGSC_v3.41187,092,235 - 187,092,492RGD
RGSC_v3.41187,092,236 - 187,092,492UniSTS
RGSC_v3.11187,242,116 - 187,242,373RGD
Celera1180,069,264 - 180,069,520UniSTS
FHH x ACI Map185.51UniSTS
FHH x ACI Map185.51RGD
Cytogenetic Map1q36UniSTS
Strain QTL Data
Symbol Name Trait
Cstrr1 Cold stress response QTL 1 catecholamine amount   (VT:0010543)    
Stresp23 Stress response QTL 23 kidney sympathetic nerve activity   (VT:0004050)    

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_phys_biochem significant increase in urinary norepinephrine, vanillylmandelic acid, and blood pressure compared to WKY animals was observed 1302892
strain_phys_biochem displays increased urinary excretion of norepinephrine (NE) and vanillylmandelic acid, increased plasma NE levels, and increased blood pressure in response to cold stress at levels greater than those observed in the parental WKY strain under cold stress 1302892
strain_phys_biochem After air-jet stress shows a significant increase in renal sympathetic nerve activity and mean arterial pressure compared with WKY strain. 1578503
strain_phys_biochem Basal membrane potential of rostral ventrolateral medulla (RVLM) neurons was less than that of WKY/Izm 2302408
strain_phys_biochem Depolarization of RVLM neurons in response to angiotensin II was larger than that of WKY/Izm 2302408

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-05-10 WKY.SHRSP-(D1Wox29-D1Arb21)/Izm    WKY.SHRSP-(D1Wox29-D1Arb21)/Izm    Name updated 68913 APPROVED
2012-05-10 WKY.SHRSP-(D1Wox29-D1Arb21)/Izm    WKY.SHRSP-(D1Wox29-D1Arb21)/Izm    Name updated 68913 APPROVED