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Strain Registration

Strain: BB/WorTky

Symbol: BB/WorTky
Strain: BB/WorTky
Substrain: WorTky
Full Name: BioBreeding rat
RGD ID: 1302634
Citation ID: RRID:RGD_1302634
Ontology ID: RS:0000070
Also Known As: NBRP Rat No: 0030; MDC-01-67
Type: inbred
Available Source: National BioResource Project for the Rat in Japan
Origination: National BioResource Project for the Rat in Japan
Description: Mutation causing diabetes mellitus in a closed colony of outbred Wistar rats at Bio-Breeding Labs, Ontario, Canada in 1974 (Chappel and Chappel 1983). To Worcester in 1977 where inbreeding began. Introduced to Tokyo Medical College in 1983.
Coat Color: albino (c)
Inbred Generations: F37
Last Known Status: Cryopreserved Embryo
Research Usage Diabetes Obesity; Immunology






References

References - curated
# Reference Title Reference Citation
1. The discovery and development of the BB rat colony: an animal model of spontaneous diabetes mellitus. Chappel CI and Chappel WR, Metabolism 1983 Jul;32(7 Suppl 1):8-10.
2. A set of highly informative rat simple sequence length polymorphism (SSLP) markers and genetically defined rat strains. Mashimo T, etal., BMC Genet. 2006 Apr 4;7:19.
3. Strains registered by the National Bio Resource Project for the Rat in Japan Personal Communication with NBRP
4. RGD Strain RSO annotation pipeline RGD Automated Pipelines
5. SNP and haplotype mapping for genetic analysis in the rat. Saar K, etal., Nat Genet. 2008 May;40(5):560-6.

Region


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_life_disease Mutation causing diabetes mellitus in a closed colony of outbred Wistar rats at Bio-Breeding Labs, Ontario, Canada in 1974. To Worcester in 1977 where inbreeding began. Sublines of diabetic-prone and diabetic-resistant animals have been developed, and there are also subline differences in the incidence, age of onset, untreated survival time of diabetes, leucopenia and body weight gain which can be attributed to genetic factors 1302452
strain_reproduction For mating injection of insulin once a day, Offspring from affected parents is crossed. 1302452

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-11-06 BB/WorTky  BioBreeding rat  BB/WorTky  biobreeding rat  Name updated 68913 APPROVED