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Strain Registration

Strain: SHR/Kyo

Symbol: SHR/Kyo
Strain: SHR
Substrain: Kyo
Full Name: spontaneous hypertension rat
RGD ID: 1302620
Citation ID: RRID:RGD_1302620
Ontology ID: RS:0000747
Also Known As: MDC-02-23; spontaneously hypertension rat; NBRP Rat No: 0013
Type: mutant
Available Source: National BioResource Project for the Rat in Japan
Origination: National BioResource Project for the Rat in Japan
Description: Okamoto 1963 from outbred Wistar Kyoto rats. Bred from a male with mild hypertension, mated with a female with high blood pressure. Brother x sister mating with continued selection for high blood pressure (Okamoto 1969, Okamoto et al 1972).
Coat Color: c
Inbred Generations: F72
Last Known Status: Live Animals; Cryopreserved Embryo; Cryopreserved Sperm (as of 2021-11-12)
Research Usage Cardio Hypertension





Experimental Data Annotations    Click to see Annotation Detail View

Rat Strain
Object SymbolSpeciesTermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
SHR/KyoRatSHR/Kyo  IEA 7241799 RGD 

Vertebrate Trait
Object SymbolSpeciesTermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
SHR/KyoRatarterial blood pressure trait  EXP 2303163 RGD 
SHR/KyoRatheart left ventricle mass  EXP 1578627 RGD 

Phenotype Values via Phenominer Click to see Annotation Detail View

Related Phenotype Data for Term "SHR/Kyo" (RS:0000747)

Rat Strains:
Clinical Measurements:
Experimental Conditions:
Measurement Methods:

Phenotype Values via PhenoMiner     Click to see Annotation Detail View
Options:  View chart  |  Download data table  |  View expanded data table

Clinical Measurement
heart rate
systolic blood pressure
body weight
body temperature
red blood cell count
blood hemoglobin level
white blood cell count
platelet count
hematocrit
mean corpuscular volume
plasma glucose level
plasma aspartate aminotransferase activity level
plasma alanine aminotransferase activity level
plasma alkaline phosphatase activity level
plasma total protein level
plasma albumin level
plasma phosphate level
plasma chloride level
plasma sodium level
plasma potassium level
heart wet weight
heart weight to body weight ratio
both kidneys wet weight
lung wet weight
urine potassium level
urine sodium level
brain weight to body weight ratio
both kidneys wet weight as percentage of body weight
liver weight as percentage of body weight
spleen weight to body weight ratio
brain wet weight
lung weight to body weight ratio
liver wet weight
both adrenal glands wet weight
spleen wet weight
both testes wet weight
activated partial thromboplastin time
prothrombin time
timed urine volume
mean corpuscular hemoglobin
mean corpuscular hemoglobin concentration
blood basophil count to total leukocyte count ratio
blood eosinophil count to total leukocyte count ratio
blood lymphocyte count to total leukocyte count ratio
blood monocyte count to total leukocyte count ratio
total plasma calcium level
urine chloride level
plasma creatinine level
plasma triglyceride level
plasma total cholesterol level
plasma urea nitrogen level
both adrenal glands weight to body weight ratio
plasma high density lipoprotein cholesterol level
plasma low density lipoprotein cholesterol level
both testes wet weight to body weight ratio
urine sodium excretion rate to body weight ratio
timed urine volume to body weight ratio
urine chloride excretion rate to body weight ratio
urine potassium excretion rate to body weight ratio
plasma total bilirubin level
blood segmented neutrophil count to total leukocyte count ratio
blood band neutrophil count to total leukocyte count ratio
non-specified leukocyte count to total leukocyte count ratio
plasma albumin to plasma total protein ratio

References

References - curated
# Reference Title Reference Citation
1. Fine mapping of Lvm1: a quantitative trait locus controlling heart size independently of blood pressure. Di Nicolantonio R, etal., Pulm Pharmacol Ther. 2006;19(1):70-3. Epub 2005 Apr 25.
2. Development of a strain of spontaneously hypertensive rats. OKAMOTO K and AOKI K, Jpn Circ J 1963 Mar;27:282-93.
3. Strains registered by the National Bio Resource Project for the Rat in Japan Personal Communication with NBRP
4. RGD Strain RSO annotation pipeline RGD Automated Pipelines
5. SNP and haplotype mapping for genetic analysis in the rat. Saar K, etal., Nat Genet. 2008 May;40(5):560-6.
6. Analysis and comparison of new candidate loci for hypertension between genetic hypertensive rat strains. Takami S, etal., Hypertens Res. 1996 Mar;19(1):51-6.

Region

Strain QTL Data
Symbol Name Trait
Bp330 Blood pressure QTL 330 arterial blood pressure trait   (VT:2000000)    
Bp331 Blood pressure QTL 331 arterial blood pressure trait   (VT:2000000)    
Bp332 Blood pressure QTL 332 arterial blood pressure trait   (VT:2000000)    
Cm49 Cardiac mass QTL 49 heart left ventricle mass   (VT:0007031)    

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_life_disease Hypertension 1302502
strain_reproduction Good breeding performance 1302502

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-11-12 SHR/Kyo  spontaneous hypertension rat  SHR/Kyo  spontaneously hypertension rat  Symbol and/or name change 68913 APPROVED
2012-05-04 SHR/Kyo  spontaneously hypertension rat  SHR/Kyo  spontaneously hypertension rat  Name updated 68913 APPROVED