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Strain Registration

Strain: DA.F344-(D10Rat204-D10Arb22)/Arb

Symbol: DA.F344-(D10Rat204-D10Arb22)/Arb
Strain: DA.F344-(D10Rat204-D10Arb22)
Substrain: Arb
RGD ID: 1299877
Citation ID: RRID:RGD_1299877
Ontology ID: RS:0001225
Also Known As: DA.F344(Cia5a); DA.F344-(D10Rat204-D10Arb22)/Arb; DA.F344-(D10Rat204-D10Arb22)/Arb
Type: congenic
Available Source: Not Available
Origination: The National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, Maryland
Description: Region of interest was introgressed from F344/Hsd into DA/BklArb by eight to ten genotype guided backcrosses followed by minimum five intercrosses.
Inbred Generations: 226
Last Known Status: Unknown
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.210104,060,133 - 104,060,283RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.010107,857,524 - 107,857,673RGD_MAPPER_PIPELINERnor6.0
Rnor_5.01094,240,348 - 107,484,761RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.41095,695,076 - 95,695,218RGD_MAPPER_PIPELINERGSC3.4





Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype

Phenotype Values via PhenoMiner     Click to see Annotation Detail View
Options:  View chart  |  Download data table  |  View expanded data table


References

References - curated
# Reference Title Reference Citation
1. The non-MHC quantitative trait locus Cia5 contains three major arthritis genes that differentially regulate disease severity, pannus formation, and joint damage in collagen- and pristane-induced arthritis. Brenner M, etal., J Immunol 2005 Jun 15;174(12):7894-903.
2. Genetic regulation of T regulatory, CD4, and CD8 cell numbers by the arthritis severity loci Cia5a, Cia5d, and the MHC/Cia1 in the rat. Brenner M, etal., Mol Med. 2007 May-Jun;13(5-6):277-87.
3. The Arthritis Severity Quantitative Trait Loci Cia4 and Cia6 Regulate Neutrophil Migration into Inflammatory Sites and Levels of TNF-{alpha} and Nitric Oxide. Laragione T, etal., J Immunol. 2007 Feb 15;178(4):2344-51.
4. Modulation of multiple experimental arthritis models by collagen-induced arthritis quantitative trait loci isolated in congenic rat lines: different effects of non-major histocompatibility complex quantitative trait loci in males and females. Remmers EF, etal., Arthritis Rheum 2002 Aug;46(8):2225-34.
5. RGD Strain RSO annotation pipeline RGD Automated Pipelines

Region

Position Markers

Flank 1 / 1 (D10Wox22)
Rat AssemblyChrPosition (strand)Source
Rnor_5.01094,240,348 - 94,240,491NCBI
RGSC_v3.41095,695,076 - 95,695,218RGD
RH 3.4 Map10981.5RGD
RH 3.4 Map10981.5UniSTS
RH 2.0 Map101084.0RGD
Cytogenetic Map10 RGD

Flank 2 / 1 (D10Arb22)
Rat AssemblyChrPosition (strand)Source
mRatBN7.210104,060,133 - 104,060,283 (+)MAPPER
Rnor_6.010107,857,524 - 107,857,673NCBI
Rnor_5.010107,484,612 - 107,484,761UniSTS
Celera10102,615,292 - 102,615,441UniSTS
Cytogenetic Map10q32.3UniSTS
Strain QTL Data
Symbol Name Trait
Cia28 Collagen induced arthritis QTL 28 joint integrity trait   (VT:0010548)    
Pia25 Pristane induced arthritis QTL 25 joint integrity trait   (VT:0010548)    

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_life_disease This strain demonstrates a reduction in collagen-induced arthritis disease severity. 629569