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Strain Registration

Strain: DA.F344-(D7Rat22-D7Mit2)/Nsi

Symbol: DA.F344-(D7Rat22-D7Mit2)/Nsi
Strain: DA.F344-(D7Rat22-D7Mit2
Substrain: Nsi
RGD ID: 1299875
Citation ID: RRID:RRRC_00679
Ontology ID: RS:0000214
Also Known As: DA.F344(Cia4); DA.F344-(D7Arb5-D7Mit2)/Arb; DA.F344-(D7Arb5-D7Mit2)/Arb; DA.F344-(D7Rat22-D7Mit2)/Arb; DA.F344-(D7Rat22-D7Mit2)/Nsi
Type: congenic
Available Source: Rat Resource and Research Center
Origination: The National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, Maryland.
Description: Congenic strain created by backcrossing F344/NHsd into DA/BklArbNsi 9 times then brother-sister mating to maintain in the homozygous state
Coat Color: agouti
Inbred Generations: 226
Last Known Status: Cryopreserved Sperm (as of 2019-02-19)
Research Usage arthritis/autoimmunity studies
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27116,294,265 - 116,294,546RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.07126,080,176 - 126,080,454RGD_MAPPER_PIPELINERnor6.0
Rnor_5.07125,794,079 - 125,794,357RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.4776,615,341 - 123,191,874RGD_MAPPER_PIPELINERGSC3.4





Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype

Phenotype Values via PhenoMiner     Click to see Annotation Detail View
Options:  View chart  |  Download data table  |  View expanded data table


References

References - curated
# Reference Title Reference Citation
1. The arthritis severity locus Cia5d is a novel genetic regulator of the invasive properties of synovial fibroblasts. Laragione T, etal., Arthritis Rheum. 2008 Aug;58(8):2296-306.
2. The Arthritis Severity Quantitative Trait Loci Cia4 and Cia6 Regulate Neutrophil Migration into Inflammatory Sites and Levels of TNF-{alpha} and Nitric Oxide. Laragione T, etal., J Immunol. 2007 Feb 15;178(4):2344-51.
3. Data registered by the Rat Resource & Research Center Personal Communication with Rat Resource & Research Center
4. Modulation of multiple experimental arthritis models by collagen-induced arthritis quantitative trait loci isolated in congenic rat lines: different effects of non-major histocompatibility complex quantitative trait loci in males and females. Remmers EF, etal., Arthritis Rheum 2002 Aug;46(8):2225-34.
5. RGD Strain RSO annotation pipeline RGD Automated Pipelines

Region

Position Markers

Flank 1 / 1 (D7Rat22)
Rat AssemblyChrPosition (strand)Source
RGSC_v3.4776,615,342 - 76,615,501UniSTS
RGSC_v3.4776,615,341 - 76,615,501RGD
RGSC_v3.1776,636,071 - 76,636,231RGD
Celera769,120,095 - 69,120,250UniSTS
RH 3.4 Map7620.3RGD
RH 3.4 Map7620.3UniSTS
RH 2.0 Map7478.6RGD
SHRSP x BN Map745.53RGD
FHH x ACI Map736.75RGD
Cytogenetic Map7q22-q31UniSTS

Flank 2 / 1 (D7Mit2)
Rat AssemblyChrPosition (strand)Source
mRatBN7.27116,294,265 - 116,294,546 (+)MAPPER
Rnor_6.07126,080,176 - 126,080,454NCBI
Rnor_5.07125,794,079 - 125,794,357UniSTS
RGSC_v3.47123,191,595 - 123,191,874RGD
RGSC_v3.47123,191,596 - 123,191,874UniSTS
RGSC_v3.17123,225,737 - 123,226,116RGD
Celera7112,592,399 - 112,592,677UniSTS
RH 3.4 Map7908.3UniSTS
RH 3.4 Map7908.3RGD
RH 2.0 Map7688.5RGD
Cytogenetic Map7 RGD

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_life_disease This strain demonstrates a significant reduction in both pristane-induced arthritis and oil-induced arthritis disease severity in male rats 629569
strain_life_disease regulates arthritis (PIA and CIA) severity, histological damage, neutrophil migration and TNF-alpha levels in the air pouch model 2292495
strain_other These have lower exudate neutrophil counts as compared to parental DA 1599708
strain_other Fibroblast-like synoviocytes (FLS) have similar number of invading cells as DA 2302383
strain_other F344 alleles between: D7Rat22 and D7Mit2. DA alleles at: D7Mit25 and D7Rat81. 2292495

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-10-14 DA.F344-(D7Rat22-D7Mit2)/Nsi    DA.F344-(D7Arb5-D7Mit2)/Arb    Symbol updated 68687 APPROVED
2013-10-14 DA.F344-(D7Rat22-D7Mit2)/Nsi    DA.F344-(D7Arb5-D7Mit2)/Arb    Name updated 68913 APPROVED
2013-10-14 DA.F344-(D7Rat22-D7Mit2)/Nsi    DA.F344-(D7Arb5-D7Mit2)/Arb    Symbol updated 68687 APPROVED
2013-10-14 DA.F344-(D7Rat22-D7Mit2)/Nsi    DA.F344-(D7Arb5-D7Mit2)/Arb    Name updated 68913 APPROVED

Database Acc Id Source(s)
RRRC RRRC:00679 RGD