Strain Report - Rat Genome Database

Name: LEW.1WR1- Ifnar1 em2
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Strain Registration

General

Strain: LEW.1WR1-Ifnar1^em2

Symbol:

LEW.1WR1-Ifnar1^em2

Strain:

LEW.1WR1-Ifnar1^em2

RGD ID:

12910494

Citation ID:

RRID:RGD_12910494

Ontology ID:

RS:0004464

Alleles:

Ifnar1^em2

Previously known as:

Ifnar1-/-LEW.1WR1; LEW.1WR1-Ifnar1em2; IFNAR1delta81+4

Type:

mutant

Source:

Department of Medicine, University of Massachusetts Medical School, Worcester, MA

Origin:

The CRISPR/Cas9 genome editing system was used to generate this mutant rat strain. The resulting strains carrying a 81-bp deletion and 4-bp insertion in exon 4 of Ifnar1 gene.

Genetic Status:

Homozygous

Last Known Status:

Unknown

Position

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	11	30,725,774 - 30,752,227	RGD_MAPPER_PIPELINE	mRatBN7.2
Rnor_6.0	11	31,640,407 - 31,666,839	RGD_MAPPER_PIPELINE	Rnor6.0
Rnor_5.0	11	35,248,575 - 35,272,235	RGD_MAPPER_PIPELINE	Rnor5.0
RGSC_v3.4	11	31,454,789 - 31,478,449	RGD_MAPPER_PIPELINE	RGSC3.4

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Cardiovirus Infections (IMP)

Experimental Diabetes Mellitus (IMP)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

decreased susceptibility to autoimmune diabetes (IMP)

increased susceptibility to viral infection induced morbidity/mortality (IMP)

insulitis (IMP)

References

References - curated

#	Reference Title	Reference Citation
1.	A Critical Role for the Type I Interferon Receptor in Virus-Induced Autoimmune Diabetes in Rats.	Qaisar N, etal., Diabetes. 2017 Jan;66(1):145-157. doi: 10.2337/db16-0462. Epub 2016 Oct 7.

Region

Additional Information

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2017-06-26	LEW.1WR1-Ifnar1^em2		SD-Ifnar1^em2		Symbol updated	68687	APPROVED
2017-06-26	LEW.1WR1-Ifnar1^em2		SD-Ifnar1^em2		Symbol updated	68687	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Strain: LEW.1WR1-Ifnar1em2

Mammalian Phenotype

Strain: LEW.1WR1-Ifnar1^em2