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Strain: SD-Thtm1(IRES-cre)Sage

Symbol: SD-Thtm1(IRES-cre)Sage
Strain: SD-Thtm1(IRES-cre)
Substrain: Sage
RGD ID: 12905029
Citation ID: RRID:RGD_12905029
Ontology ID: RS:0004451
Previously known as: TGRA8400 ; SD- Th-cre tm1sage; Tyrosine Hydroxylase TH-Cre Rat
Type: mutant
Source: Horizon Discovery
Origin: This ZFN knock in model expresses cre-recombinase under the control of the endogenous tyrosine hydroxylase promoter enabling specific expression in dopaminergic neurons. This model possesses a targeted insertion of (IRES)-cre immediately after the translational stop in the open reading frame of Th. The TH-Cre rat is useful for applications requiring tissue specific expression, including optogenetics and breeding with transgenic floxed lines.
Genetic Status: Homozygous
Last Known Status: Live Animals (as of 2017-05-31)
Research Usage Optogenetics Rats


References - curated
# Reference Title Reference Citation
1. Tissue Specific Expression of Cre in Rat Tyrosine Hydroxylase and Dopamine Active Transporter-Positive Neurons. Liu Z, etal., PLoS One. 2016 Feb 17;11(2):e0149379. doi: 10.1371/journal.pone.0149379. eCollection 2016.


Additional Information

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-11-27 SD-Thtm1(IRES-cre)Sage    SD-Tg(Th-cre)Sage    Symbol updated 68687 APPROVED
2018-11-27 SD-Thtm1(IRES-cre)Sage    SD-Tg(Th-cre)Sage    Symbol updated 68687 APPROVED