Strain: SD-Lepem1Sage

Symbol: SD-Lepem1Sage
Strain: SD-Lepem1
Substrain: Sage
Ontology ID: RS:0004449
Alleles: Lepem1Sage
Also known as: SD- Lep tm1sage; Leptin Knockout Rat -KiloRat-TM; TGRA3780 ; SD-Lepem1Sage
Type: mutant
Source: Horizon Discovery
Origin: This ZFN model possesses a 151 bp deletion spanning exon 1/intron 1 junction of Leptin gene. Homozygous knockout rats display loss of Leptin protein via Western blot. Homozygous knockout rats demonstrate significant weight gain compared to wild type littermates. Homozygous knockout rats show significantly elevated serum cholesterol levels
Genetic Status: Heterozygous
Last Known Status: Cryopreserved Embryo (as of 2017-05-24)
Research Usage Cardiovascular
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0456,337,695 - 56,351,818RGD_MAPPER_PIPELINERnor6.0
Rnor_5.0456,085,079 - 56,099,209RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.4455,943,837 - 55,945,938RGD_MAPPER_PIPELINERGSC3.4

Disease Annotations
Phenotype Annotations
Experimental Data Annotations
References - curated
RGD Disease Portals


Additional Information

More on this Strain
Strain Nomenclature
Strain Registration

RGD Object Information
RGD ID: 12904912
Created: 2017-05-24
Species: Rattus norvegicus
Last Modified: 2017-05-24
Status: ACTIVE