Strain: SD-Bdnfem1Sage

Symbol: SD-Bdnfem1Sage
Strain: SD-Bdnfem1
Substrain: Sage
Ontology ID: RS:0004426
Alleles: Bdnfem1Sage
Also known as: BDNF Knockout Rat; SD- Bdnf tm1sage; TGRS3850 ; SD-Bdnfem1Sage
Type: mutant
Source: Horizon Discovery
Origin: This ZFN model contains a monoallelic deletion of the Bdnf gene, encoding for the nerve growth factor protein BDNF. Homozygous animals carrying the Bdnf deletion are postnatal lethal. Reductions of BDNF have been observed in patients with Alzheimer's disease (AD), and this model may be useful for understanding the role of BDNF in AD.
Genetic Status: Heterozygous
Last Known Status: Live Animals (as of 2017-06-20)
Research Usage Schizophrenia and Alzheimer's Disease
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.03100,768,637 - 100,819,216RGD_MAPPER_PIPELINERnor6.0
Rnor_5.03107,371,329 - 107,421,908RGD_MAPPER_PIPELINERnor5.0

Experimental Data Annotations


Additional Information

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Strain Nomenclature
Strain Registration

RGD Object Information
RGD ID: 12902621
Created: 2017-05-09
Species: Rattus norvegicus
Last Modified: 2017-05-09
Status: ACTIVE