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Strain Registration

Strain: GK/Wnsm

Symbol: GK/Wnsm
Strain: GK
Substrain: Wnsm
RGD ID: 127284837
Citation ID: RRID:RGD_127284837
Ontology ID: RS:0004950
Type: inbred
Source: University of Wales College of Medicine (Cardiff, UK)
Origin: The Goto-Kakizaki (GK) rat is a non-obese Wistar substrain which develops Type 2 diabetes mellitus early in life. The model was developed by Goto and Kakizaki at Tohoku University, Sendai, Japan in 1975. The GK line was established by repeated inbreeding from Wistar rats selected at the upper limit of normal distribution for glucose tolerance. Repeated selection of rats with tendency to lowest glucose tolerance resulted in clear-cut glucose intolerance after five generations. This GK/Wnsm colony was established at the University of Wales College of Medicine (Cardiff, UK) after received breeding pairs provided by Professor Y Goto (Tohoku University School of Medicine, Sendai, Japan).
Last Known Status: Unknown





References

References - curated
# Reference Title Reference Citation
1. Cardiac dysfunction in the Goto-Kakizaki rat. A model of type II diabetes mellitus. El-Omar MM, etal., Basic Res Cardiol. 2004 Mar;99(2):133-41. doi: 10.1007/s00395-004-0440-4. Epub 2003 Oct 7.

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