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Strain: SD-Cryba1Nuc1Dbsa

Symbol: SD-Cryba1Nuc1Dbsa
Strain: SD-Cryba1Nuc1
Substrain: Dbsa
RGD ID: 126925756
Citation ID: RRID:RGD_126925756
Ontology ID: RS:0004944
Alleles: Cryba1Nuc1Dbsa
Type: mutant
Source: The Johns Hopkins University School of Medicine The Wilmer Eye Institute The Johns Hopkins University School of Medicine Baltimore
Origin: This spontaneous mutation was identified in the offspring of pregnant Sprague-Dawley rats purchased from Taconic Farms. This mutant exhibited abnormal eye phenotype including nuclear cataracts and was called Nuc1 rat. Sequencing of the mutant allele revealed a 27 base pair insertion in exon 6 of Cryba1.
Last Known Status: Unknown
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21062,608,373 - 62,614,726RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.01065,160,777 - 65,167,504RGD_MAPPER_PIPELINERnor6.0
Rnor_5.01066,458,061 - 66,480,390RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.41063,758,929 - 63,765,451RGD_MAPPER_PIPELINERGSC3.4


References - curated
# Reference Title Reference Citation
1. A spontaneous mutation affects programmed cell death during development of the rat eye. Sinha D, etal., Exp Eye Res. 2005 Mar;80(3):323-35. doi: 10.1016/j.exer.2004.09.014.
2. betaA3/A1-crystallin in astroglial cells regulates retinal vascular remodeling during development. Sinha D, etal., Mol Cell Neurosci. 2008 Jan;37(1):85-95. Epub 2007 Aug 31.
3. Mutation in the βA3/A1-crystallin gene impairs phagosome degradation in the retinal pigmented epithelium of the rat. Zigler JS, etal., J Cell Sci. 2011 Feb 15;124(Pt 4):523-31. doi: 10.1242/jcs.078790. Epub 2011 Jan 25.


Additional Information

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-05-19 SD-Cryba1Nuc1Dbsa    SD-Cryba1-Nuc1Dbsa    Symbol and/or name change 68913 APPROVED