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Strain: SHR-Zbtb16em1Ipcv+/-

Symbol: SHR-Zbtb16em1Ipcv+/-
Strain: SHR-Zbtb16em1+/-
Substrain: Ipcv
RGD ID: 126848794
Citation ID: RRID:RGD_126848794
Ontology ID: RS:0005033
Alleles: Zbtb16em1Ipcv
Previously known as: SHR-Plzfem1Ipcv+/-
Type: mutant
Source: Institute of Biology and Medical Genetics, Charles University, Prague
Origin: TALEN was used to target Zbtb16 (Plzf )in the SHR and one founder with a deletion of G at position 93 of the coding sequence (c.93delG) was identified. That deletion resulted in a frameshift downstream glycine 31 (p.Gly31fs). The frameshift mutation caused the incorporation of 20 aberrant amino acids downstream of the deleted G, followed by a stop codon. The founder was bred with SHR to generate more heterozygous animals. The homozygous animals die perinatally because of multiple developmental abnormalities.
Genetic Status: Heterozygous
Last Known Status: Unknown
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2848,989,376 - 49,177,011RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.0852,980,226 - 53,146,765RGD_MAPPER_PIPELINERnor6.0
Rnor_5.0851,573,252 - 51,740,759RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.4851,931,530 - 52,094,813RGD_MAPPER_PIPELINERGSC3.4


References - curated
# Reference Title Reference Citation
1. Downregulation of Plzf Gene Ameliorates Metabolic and Cardiac Traits in the Spontaneously Hypertensive Rat. Liška F, etal., Hypertension. 2017 Jun;69(6):1084-1091. doi: 10.1161/HYPERTENSIONAHA.116.08798. Epub 2017 Apr 10.


Additional Information

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-08-20 SHR-Zbtb16em1Ipcv+/-    SHR-Plzfem1Ipcv+/-    Symbol and/or name change 68913 APPROVED