Strain Report - Rat Genome Database

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Strain: SD-Shank2em13Sage

Symbol: SD-Shank2em13Sage
Strain: SD-Shank2em13
Substrain: Sage
RGD ID: 126790496
Citation ID: RRID:RGD_126790496
Ontology ID: RS:0004922
Alleles: Shank2em13Sage
Type: mutant
Source: Not Available
Origin: The Shank2 KO rat line 13 was generated by zinc finger nuclease technology targeting exon 31 for deletion . Line 13 has a 437 bp deletion around and including the entire exon 31, thereby causing a frameshift and premature stop codon in all three known isoforms of the rat Shank2 mRNA
Genetic Status: Homozygous
Last Known Status: Unknown
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21199,146,210 - 199,590,962RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.01217,149,156 - 217,593,950RGD_MAPPER_PIPELINERnor6.0
Rnor_5.01222,118,530 - 224,450,737RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.41204,399,856 - 204,855,474RGD_MAPPER_PIPELINERGSC3.4


References - curated
# Reference Title Reference Citation
1. Hyperactivity and Hypermotivation Associated With Increased Striatal mGluR1 Signaling in a Shank2 Rat Model of Autism. Modi ME, etal., Front Mol Neurosci. 2018 Jun 19;11:107. doi: 10.3389/fnmol.2018.00107. eCollection 2018.


Additional Information