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Strain Registration

Strain: SD-Nlgn3em1Sage

Symbol: SD-Nlgn3em1Sage
Strain: SD-Nlgn3em1
Substrain: Sage
RGD ID: 11568700
Citation ID: RRID:RGD_11568700
Ontology ID: RS:0004311
Alleles: Nlgn3em1Sage
Also Known As: SD-Nlgn3tm1Sage; TGRS6650; SD-Nlgn3em1Sage; SD-Nlgn3^[em1Sage]
Type: mutant
Available Source: Horizon Discovery
Origination: Horizon Discovery
Description: The ZFN mutant rat strain was produced by injecting zinc finger nuclease targeting rat Nlgn3 into Sprague Dawley embryos. Homozygous knockout rats exhibit complete loss of target protein as demonstrated by Western blot.
Genetic Status: Heterozygous
Last Known Status: Live Animals; Cryopreserved Embryo (as of 2016-12-13)
Research Usage Autism, Asperger's syndrome, Synaptic plasticity
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8X70,469,251 - 70,497,380RGD_MAPPER_PIPELINE
mRatBN7.2X66,439,348 - 66,439,405RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.0X71,209,388 - 71,209,445RGD_MAPPER_PIPELINERnor6.0
Rnor_5.0X72,051,846 - 72,075,119RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.4X89,376,193 - 89,398,665RGD_MAPPER_PIPELINERGSC3.4





References

References - curated
# Reference Title Reference Citation
1. Fmr1 and Nlgn3 knockout rats: novel tools for investigating autism spectrum disorders. Hamilton SM, etal., Behav Neurosci. 2014 Apr;128(2):103-9. doi: 10.1037/a0035988.
2. Sleep/Wake Physiology and Quantitative Electroencephalogram Analysis of the Neuroligin-3 Knockout Rat Model of Autism Spectrum Disorder. Thomas AM, etal., Sleep. 2017 Oct 1;40(10). pii: 4100612. doi: 10.1093/sleep/zsx138.

Region

Allelic Variants
Name Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Assembly
Nlgn3em1Sage-var1 chrX 66439348 66439405 CAACTACCGGGTCGGGGTGCTAGGTATGGTTCTCTGCCAGGTGCCTAGGAGGAAGGCT - deletion mRatBN7.2
Nlgn3em1Sage-var1 chrX 71209388 71209445 CAACTACCGGGTCGGGGTGCTAGGTATGGTTCTCTGCCAGGTGCCTAGGAGGAAGGCT - deletion Rnor_6.0

Additional Information