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Strain: SD-Mecp2em1Sage

Symbol: SD-Mecp2em1Sage
Strain: SD-Mecp2em1
Substrain: Sage
RGD ID: 11567272
Citation ID: RRID:RGD_11567272
Ontology ID: RS:0005253
Alleles: Mecp2em1Sage
Also Known As: SD-Mecp2tm1sage; TGRA6090; SD-Mecp2em1Sage; Sage:SD-Mecp2tm1Sage; MeCP2 knockout rat; SD-Mecp2^[em1Sage]
Type: mutant
Available Source: Horizon Discovery
Origination: Horizon Discovery
Description: The ZFN mutant rat strain was produced by injecting zinc finger nuclease targeting rat Mecp2 into Sprague Dawley embryos. This mutant rat has a knockout of the methyl CpG binding protein 2 (Mecp2).
Genetic Status: Heterozygous
Last Known Status: Live Animals (as of 2016-12-13)
Research Usage Autism, Rett syndrome, Cognition
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X151,781,177 - 151,844,687RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.0X156,650,389 - 156,713,813RGD_MAPPER_PIPELINERnor6.0
Rnor_5.01152,390,961 - 152,461,647RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.4X159,980,599 - 160,035,260RGD_MAPPER_PIPELINERGSC3.4

Substrains
SD-Mecp2em1Sage/Hsd

Mutant Strains
SD-Mecp2em1Sage/Hsd




References

References - curated
# Reference Title Reference Citation
1. Degraded neural and behavioral processing of speech sounds in a rat model of Rett syndrome. Engineer CT, etal., Neurobiol Dis. 2015 Nov;83:26-34. doi: 10.1016/j.nbd.2015.08.019. Epub 2015 Aug 28.
2. MeCP2 deficiency results in robust Rett-like behavioural and motor deficits in male and female rats. Patterson KC, etal., Hum Mol Genet. 2016 Aug 1;25(15):3303-3320. doi: 10.1093/hmg/ddw179. Epub 2016 Jun 21.
3. Loss of MeCP2 in the rat models regression, impaired sociability and transcriptional deficits of Rett syndrome. Veeraragavan S, etal., Hum Mol Genet. 2016 Jun 30. pii: ddw178.
4. Characterization of Rett Syndrome-like phenotypes in Mecp2-knockout rats. Wu Y, etal., J Neurodev Disord. 2016 Jun 16;8:23. doi: 10.1186/s11689-016-9156-7. eCollection 2016.

Region


Additional Information


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-12-06 SD-Mecp2em1Sage    SD-Mecp2em1Sage  methyl CpG binding protein 2;zinc finger nuclease induced mutant 1, Sigma Advanced Genetic Engineering Labs  Name updated 68913 APPROVED
2016-12-06 SD-Mecp2em1Sage    SD-Mecp2em1Sage  methyl CpG binding protein 2;zinc finger nuclease induced mutant 1, Sigma Advanced Genetic Engineering Labs  Name updated 68913 APPROVED