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Strain Registration

Strain: SCR/Sscr

Symbol: SCR/Sscr
Strain: SCR
Substrain: Sscr
Full Name: Shumiya Cataract Rat
RGD ID: 11564350
Citation ID: RRID:RGD_11564350
Ontology ID: RS:0004284
Alleles: Lss;   Fdft1
Also Known As: NBRP Rat No: 0823; Shumiya Cataract Rat
Type: congenic
Available Source: Not Available
Photo
Description: Genetic Cataract rat SCR（Shumiya Cataract Rat）was segrigated from a SHR-fa strain colony that developed nuclear cataract at adult stage. This strain is a double mutant caused by recessive gene (ctr1) and dominant lethal gene (Ctr2l) and established by Dr. Shumiya at Tokyo Metropolitan Institute of Gerontology. In 2003, this strain was introduced to Kyoritsu College of Pharmacy (keio University Faculty of Pharmacy). ctr1 is lanosterol synthase (Lss) and Ctr2 is farnesyl diphosphate farnesyl transferase 1 (Fdft1).
Inbred Generations: F544
Last Known Status: Cryopreserved Embryo (as of 2016-11-16)





Disease Annotations     Click to see Annotation Detail View
cataract  (IAGP)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype

References

References - curated
# Reference Title Reference Citation
1. Lanosterol synthase mutations cause cholesterol deficiency-associated cataracts in the Shumiya cataract rat. Mori M, etal., J Clin Invest. 2006 Feb;116(2):395-404. Epub 2006 Jan 26.

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